BepiPred‐3.0: Improved B‐cell epitope prediction using protein language models

JN Clifford, MH Høie, S Deleuran, B Peters… - Protein …, 2022 - Wiley Online Library
B‐cell epitope prediction tools are of great medical and commercial interest due to their
practical applications in vaccine development and disease diagnostics. The introduction of …

Multi‐perspectives and challenges in identifying B‐cell epitopes

N Kumar, N Bajiya, S Patiyal, GPS Raghava - Protein Science, 2023 - Wiley Online Library
The identification of B‐cell epitopes (BCEs) in antigens is a crucial step in developing
recombinant vaccines or immunotherapies for various diseases. Over the past four decades …

The ClusPro AbEMap web server for the prediction of antibody epitopes

IT Desta, S Kotelnikov, G Jones, U Ghani, M Abyzov… - Nature protocols, 2023 - nature.com
Antibodies play an important role in the immune system by binding to molecules called
antigens at their respective epitopes. These interfaces or epitopes are structural entities …

Designing a multi-epitope peptide based vaccine against SARS-CoV-2

A Singh, M Thakur, LK Sharma, K Chandra - Scientific reports, 2020 - nature.com
COVID-19 pandemic has resulted in 16,114,449 cases with 646,641 deaths from the 217
countries, or territories as on July 27th 2020. Due to multifaceted issues and challenges in …

Designing a multi-epitope vaccine against Mycobacteroides abscessus by pangenome-reverse vaccinology

HA Dar, S Ismail, Y Waheed, S Ahmad, Z Jamil… - Scientific reports, 2021 - nature.com
Abstract Mycobacteroides abscessus (Previously Mycobacterium abscessus) is an emerging
microorganism of the newly defined genera Mycobacteroides that causes mainly skin and …

Bioinformatics, computational informatics, and modeling approaches to the design of mRNA COVID-19 vaccine candidates

OO Oluwagbemi, EK Oladipo, OM Kolawole, JK Oloke… - Computation, 2022 - mdpi.com
This article is devoted to applying bioinformatics and immunoinformatics approaches for the
development of a multi-epitope mRNA vaccine against the spike glycoproteins of circulating …

iLBE for computational identification of linear B-cell epitopes by integrating sequence and evolutionary features

MM Hasan, MS Khatun, H Kurata - Genomics, Proteomics and …, 2020 - academic.oup.com
Linear B-cell epitopes are critically important for immunological applications, such as
vaccine design, immunodiagnostic test, and antibody production, as well as disease …

EpitopeVec: linear epitope prediction using deep protein sequence embeddings

A Bahai, E Asgari, MRK Mofrad, A Kloetgen… - …, 2021 - academic.oup.com
Motivation B-cell epitopes (BCEs) play a pivotal role in the development of peptide vaccines,
immuno-diagnostic reagents and antibody production, and thus in infectious disease …

Biolayer interferometry-SELEX for Shiga toxin antigenic-peptide aptamers & detection via chitosan-WSe2 aptasensor

H Kaur, M Shorie, P Sabherwal - Biosensors and Bioelectronics, 2020 - Elsevier
We report biolayer interferometry based in-vitro selection technique (BLI-SELEX) for fishing
out specific aptamers against E. coli Shiga toxin subtypes viz., stx1 & stx2 via epitopic …

B-cell epitope peptide cancer vaccines: a new paradigm for combination immunotherapies with novel checkpoint peptide vaccine

PTP Kaumaya - Future Oncology, 2020 - Taylor & Francis
In light of the numerous US FDA-approved humanized monoclonal antibodies (mAbs) for
cancer immunotherapy, it is surprising that the advancement of B-cell epitope vaccines …