[HTML][HTML] Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer's disease
Alzheimer's disease (AD) is the most common neurodegenerative disorder seen in age-
dependent dementia. There is currently no effective treatment for AD, which may be …
dependent dementia. There is currently no effective treatment for AD, which may be …
[HTML][HTML] Endo-lysosomal dysregulations and late-onset Alzheimer's disease: impact of genetic risk factors
ZP Van Acker, M Bretou, W Annaert - Molecular neurodegeneration, 2019 - Springer
Increasing evidence supports that cellular dysregulations in the degradative routes
contribute to the initiation and progression of neurodegenerative diseases, including …
contribute to the initiation and progression of neurodegenerative diseases, including …
A single-cell atlas of entorhinal cortex from individuals with Alzheimer's disease reveals cell-type-specific gene expression regulation
There is currently little information available about how individual cell types contribute to
Alzheimer's disease. Here we applied single-nucleus RNA sequencing to entorhinal cortex …
Alzheimer's disease. Here we applied single-nucleus RNA sequencing to entorhinal cortex …
Molecular subtyping of Alzheimer's disease using RNA sequencing data reveals novel mechanisms and targets
Alzheimer's disease (AD), the most common form of dementia, is recognized as a
heterogeneous disease with diverse pathophysiologic mechanisms. In this study, we …
heterogeneous disease with diverse pathophysiologic mechanisms. In this study, we …
[HTML][HTML] Spatially resolved transcriptomics reveals genes associated with the vulnerability of middle temporal gyrus in Alzheimer's disease
Human middle temporal gyrus (MTG) is a vulnerable brain region in early Alzheimer's
disease (AD), but little is known about the molecular mechanisms underlying this regional …
disease (AD), but little is known about the molecular mechanisms underlying this regional …
[HTML][HTML] Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer's disease
Background Disease-associated-microglia (DAM) represent transcriptionally-distinct and
neurodegeneration-specific microglial profiles with unclear significance in Alzheimer's …
neurodegeneration-specific microglial profiles with unclear significance in Alzheimer's …
Untangling genetic risk for Alzheimer's disease
Alzheimer's disease (AD) is a genetically heterogeneous neurodegenerative disorder
caused by fully penetrant single gene mutations in a minority of cases, while the majority of …
caused by fully penetrant single gene mutations in a minority of cases, while the majority of …
[HTML][HTML] BIN1 favors the spreading of Tau via extracellular vesicles
A Crotti, HR Sait, KM McAvoy, K Estrada, A Ergun… - Scientific Reports, 2019 - nature.com
Abstract Despite Bridging INtegrator 1 (BIN1) being the second most statistically-significant
locus associated to Late Onset Alzheimer's Disease, its role in disease pathogenesis …
locus associated to Late Onset Alzheimer's Disease, its role in disease pathogenesis …
[HTML][HTML] BIN1 is a key regulator of proinflammatory and neurodegeneration-related activation in microglia
Background The BIN1 locus contains the second-most significant genetic risk factor for late-
onset Alzheimer's disease. BIN1 undergoes alternate splicing to generate tissue-and cell …
onset Alzheimer's disease. BIN1 undergoes alternate splicing to generate tissue-and cell …
Dissecting the complexities of Alzheimer disease with in vitro models of the human brain
Alzheimer disease (AD) is the most prevalent type of dementia. It is marked by severe
memory loss and cognitive decline, and currently has limited effective treatment options …
memory loss and cognitive decline, and currently has limited effective treatment options …