Two concepts for the long-term regulation of arterial pressure were considered in this
review, the neural control hypothesis and the volume regulation hypothesis. The role of the …

OBJECTIVES: Prostaglandins are a group of biologically active compounds that play major
roles in human physiology in both health and disease. They function in many different ways …

The recognition that the endoplasmic reticulum (ER), rather than the mitochondria, is the
main organelle regulating the cytoplasmic Ca2+ concentration in non-muscle cells1, 2 …

The function of the nephron, the anatomical unit of the kidney, is segmented; at least 12
segments have been identified that differ in their morphology, transport properties and …

The protean properties of 20-hydroxyeicosatetraenoic acid (HETE), vasoactivity,
mitogenicity, and modulation of transport in key nephron segments, serve as the basis for …

The cytochrome P-450 pathway of AA metabolism is widely distributed and gives rise to a
diversity of products affecting basic biological mechanisms such as vascular reactivity and …

Purified synthetic products from the cytochrome P450 pathway of arachidonate metabolism
were applied to the intestinal serosa. Arteriolar blood flow was calculated using video …

Certain epoxyeicosatrienoic acids (EETs) that were not cyclooxygenase substrates were
effective cyclooxygenase inhibitors. Both (+/-)-14, 15-cis-EET and (+/-)-8, 9-cis-EET inhibited …

In the medullary segment of the thick ascending limb of the loop of Henle (mTALH),
arachidonic acid (AA) is metabolized by a cytochrome P450-dependent monooxygenase to …

This review discusses the metabolism of arachidonic acid to prostaglandins (PG) and other
metabolites and the site of physiological action of these products along the nephron …