Alpha macroglobulins are large glycoproteins which are present in the body fluids of both
invertebrates and vertebrates. Alpha‐2‐macroglobulin (α2M), a key member of alpha …

Single-celled organisms must adapt their physiology to persist and propagate across a wide
range of environmental conditions. The growth and division of bacterial cells depend on …

Highlights•Neutrophil serine proteases (NSPs) support bacterial clearance by
neutrophils.•NSPs can kill bacteria, generate antimicrobial peptides or induce NET …

Serine protease inhibitors, inhibit serine proteases either partially or completely after forming
complexes with their respective proteases. Protease actions are significant for many …

Abstract α 2-macroglobulins are broad-spectrum endopeptidase inhibitors, which have to
date been characterised from metazoans (vertebrates and invertebrates) and Gram-negative …

Tailoring of the activity and specificity of proteases is critical for their utility across industrial,
medical and research purposes. However, engineering or evolving protease catalysts is …

Analytical ultracentrifugation is one of the most powerful solution techniques for the study of
macromolecular interactions, to define the number and stoichiometry of complexes formed …

Human α2-macroglobulin (hα2M) is a multidomain protein with a plethora of essential
functions, including transport of signaling molecules and endopeptidase inhibition in innate …

Abstract Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad
range of proteases and are major components of the eukaryotic innate immune system …

The survival of commensal bacteria requires them to evade host peptidases. Gram-negative
bacteria from the human gut microbiome encode a relative of the human endopeptidase …