Trypanosoma brucei is a pathogenic unicellular eukaryote that infects humans and other
mammals in sub-Saharan Africa. A central feature of trypanosome biology is the single …

A defining feature of Trypanosoma brucei cell shape is the lateral attachment of the
flagellum to the cell body, mediated by the flagellum attachment zone (FAZ). The FAZ is a …

Intercellular communication between parasites and with host cells provides mechanisms for
parasite development, immune evasion, and disease pathology. Bloodstream African …

One of the first steps in understanding a protein's function is to determine its localization;
however, the methods for localizing proteins in some systems have not kept pace with the …

The African trypanosome, Trypanosoma brucei, maintains an integral link between cell cycle
regulation and differentiation during its intricate life cycle. Whilst extensive changes in …

Prostate cancer is a heterogeneous disease composed of divergent molecular and
histologic subtypes, including prostate adenocarcinoma (PrAd) and neuroendocrine …

The protozoan parasite Leishmania possesses a single flagellum, which is remodelled
during the parasite's life cycle from a long motile flagellum in promastigote forms in the sand …

Cilia and flagella are complex organelles made of hundreds of proteins of highly variable
structures and functions. Here we report the purification of intact flagella from the procyclic …

The parasite Trypanosoma brucei possesses a large family of transmembrane receptor–like
adenylate cyclases. Activation of these enzymes requires the dimerization of the catalytic …

Background Trypanosoma brucei is the causative agent of human African sleeping sickness
and Nagana in cattle. In addition to being an important pathogen T. brucei has developed …