Neurodegenerative diseases are the most common cause of dementia. Although their
underlying molecular pathologies have been identified, there is substantial heterogeneity in …

Abstract α-Synuclein and tau are abundant multifunctional brain proteins that are mainly
expressed in the presynaptic and axonal compartments of neurons, respectively. Previous …

Phosphorylation of α-synuclein at the serine-129 site (α-syn Ser129P) is an established
pathologic hallmark of synucleinopathies and a therapeutic target. In physiologic states, only …

Abstract α-Synuclein (αSYN), a pivotal synaptic protein implicated in synucleinopathies such
as Parkinson's disease and Lewy body dementia, undergoes protein phase separation. We …

Various forms of Parkinson's disease, including its common sporadic form, are characterized
by prominent α‐synuclein (αSyn) aggregation in affected brain regions. However, the role of …

α-Synuclein is a presynaptic protein that regulates synaptic vesicle (SV) trafficking. In
Parkinson's disease (PD) and dementia with Lewy bodies (DLB), α-synuclein aberrantly …

Parkinson's disease (PD) and Dementia with Lewy bodies (DLB) are characterized by
neuronal α-synuclein (α-syn) inclusions termed Lewy Pathology, which are abundant in the …

Parkinson's disease (PD) pathology is characterized by the loss of dopaminergic neurons of
the nigrostriatal system and accumulation of Lewy bodies (LB) and Lewy neurites (LN) …

Parkinson's disease (PD) is a common neurodegenerative movement disorder,
characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta …

Parkinson's disease (PD) has two main pathological hallmarks, the loss of nigral dopamine
neurons and the proteinaceous aggregations of⍺-synuclein (⍺ Syn) in neuronal Lewy …