Uncovering the cis-regulatory code that governs when and how much each gene is
transcribed in a given genome and cellular state remains a central goal of biology. Here, we …

The packaging of DNA into chromatin in eukaryotes regulates gene transcription, DNA
replication and DNA repair. ATP-dependent chromatin remodelling enzymes (re) arrange …

Chromatin accessibility is a hallmark of active transcription and entails ATP-dependent
nucleosome remodeling, which is carried out by complexes such as Brahma-associated …

Large-scale cancer genome sequencing studies have revealed that chromatin regulators
are frequently mutated in cancer. In particular, more than 20% of cancers harbour mutations …

ARID1A, a subunit of the canonical BAF nucleosome remodeling complex, is commonly
mutated in lymphomas. We show that ARID1A orchestrates B cell fate during the germinal …

Pioneer factors are a group of transcription factors with important roles in gene regulation
during development. Their unique ability to bind to compacted chromatin, promoting its …

Eukaryotic transcription factors (TFs) are the final integrators of a complex molecular
feedback mechanism that interfaces with the genome, consolidating information for …

The rate at which cells enter the T cell pathway depends not only on the immigration of
hematopoietic precursors into the strong Notch signaling environment of the thymus but also …

In sexually reproducing organisms, life begins with the fusion of transcriptionally silent
gametes, the oocyte and sperm. Although initiation of transcription in the embryo, known as …

In development, pioneer transcription factors access silent chromatin to reveal lineage-
specific gene programs. The structured DNA-binding domains of pioneer factors have been …