Statistical crystallography reveals an allosteric network in SARS-CoV-2 Mpro

A Creon, E Scheer, PYA Reinke, AR Mashhour… - bioRxiv, 2025 - biorxiv.org
To interpret and transmit biological signals, proteins use correlated motions. Experimental
determination of these dynamics with atomic resolution remains a key challenge. Here …

Three STEPs forward: A trio of unexpected structures of PTPN5

L Guerrero, A Ebrahim, BT Riley, SH Kim, AC Bishop… - bioRxiv, 2024 - biorxiv.org
Protein tyrosine phosphatases (PTPs) play pivotal roles in myriad cellular processes by
counteracting protein tyrosine kinases. Striatal-enriched protein tyrosine phosphatase …