Targeting of CD163+ Macrophages in Inflammatory and Malignant Diseases

MK Skytthe, JH Graversen, SK Moestrup - International journal of …, 2020 - mdpi.com
The macrophage is a key cell in the pro-and anti-inflammatory response including that of the
inflammatory microenvironment of malignant tumors. Much current drug development in …

[HTML][HTML] Subclinical doxorubicin-induced cardiotoxicity update: role of neutrophils and endothelium

VK Todorova, JY Wei, I Makhoul - American Journal of Cancer …, 2021 - ncbi.nlm.nih.gov
Doxorubicin (DOX) is a highly effective chemotherapy agent that often causes cardiotoxicity.
Despite a number of extensive studies, the risk for DOX cardiotoxicity remains unpredictable …

SGLT2 inhibitor dapagliflozin alleviates intramyocardial hemorrhage and adverse ventricular remodeling via suppressing hepcidin in myocardial ischemia-reperfusion …

R Chen, Y Zhang, H Zhang, H Zhou, W Tong… - European Journal of …, 2023 - Elsevier
Intramyocardial hemorrhage (IMH), a reperfusion therapy-associated complication, is the
extravasation of red blood cells caused by severe microvascular injury. IMH is an …

Inflammation and remodeling pathways and risk of cardiovascular events in patients with ischemic heart failure and reduced ejection fraction

N Girerd, J Cleland, SD Anker, W Byra, CSP Lam… - Scientific reports, 2022 - nature.com
Patients with heart failure (HF) and coronary artery disease (CAD) have a high risk for
cardiovascular (CV) events including HF hospitalization, stroke, myocardial infarction (MI) …

Insights into the associations between the gut microbiome, its metabolites, and heart failure

AF Ahmad, JA Caparrós-Martin… - American Journal …, 2023 - journals.physiology.org
Heart failure (HF) is the end stage of most cardiovascular diseases and remains a significant
health problem globally. We aimed to assess whether patients with left ventricular ejection …

Dynamic personalized risk prediction in chronic heart failure patients: a longitudinal, clinical investigation of 92 biomarkers (Bio-SHiFT study)

D Klimczak-Tomaniak, M de Bakker, E Bouwens… - Scientific reports, 2022 - nature.com
The aim of our observational study was to derive a small set out of 92 repeatedly measured
biomarkers with optimal predictive capacity for adverse clinical events in heart failure, which …

[HTML][HTML] Peripheral neutrophils and naive CD4 T cells predict the development of heart failure following acute myocardial infarction: A bioinformatic study

C Yu, W Zhou - Revista Portuguesa de Cardiologia (English Edition), 2021 - Elsevier
Introduction Heart failure (HF) secondary to acute myocardial infarction (AMI) is still a
worldwide problem with a high mortality rate. The current study aimed to explore early and …

Circulating PGLYRP1 levels as a potential biomarker for coronary artery disease and heart failure

Y Han, S Hua, Y Chen, W Yang, W Zhao… - Journal of …, 2021 - journals.lww.com
Coronary artery disease (CAD) and associated comorbidities such as heart failure (HF)
remain the leading cause of morbidity and mortality worldwide attributed to, at least partially …

Increased circulating progranulin is not sufficient to induce cardiac dysfunction or supraventricular arrhythmia

KE McElhanon, TC Huff, D Hirenallur-Shanthappa… - Scientific Reports, 2023 - nature.com
Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia, and the incidence of new-
onset AF has been increasing over the past two decades. Several factors contribute to the …

Sex‐specific cardiovascular protein levels and their link with clinical outcome in heart failure

M de Bakker, M Loncq de Jong, T Petersen… - ESC Heart …, 2024 - Wiley Online Library
Aims This study aims to provide insight into sex‐specific cardiovascular protein profiles and
their associations with adverse outcomes, which may contribute to a better understanding of …