We have examined factors concerned with the maintenance of uterine quiescence during
pregnancy and the onset of uterine activity at term in an animal model, the sheep, and in …

A comprehensive number of epidemiological and animal studies suggests that prenatal and
early life events are important determinants for disorders later in life. Among them, prenatal …

An adverse early-life environment is associated with long-term disease consequences.
Adversity early in life is hypothesized to elicit developmental adaptations that serve to …

New Findings What is the topic of this review? This review discusses the role of the
glucocorticoids as regulatory signals during intrauterine development. It examines the …

I. Introduction P RETERM labor and prematurity with immaturity remain major problems in
clinical obstetric practice. In North America approximately 5–8% of all deliveries occur …

In mammals, including man, epidemiological and experimental studies have shown that a
range of environmental factors acting during critical periods of early development can alter …

We investigated the effects of moderate maternal periconceptional undernutrition from 60 d
before to 30 d after mating on fetal hypothalamic-pituitary-adrenal axis function in late …

Glucocorticoids (GCs) are important environmental and maturational signals during
intrauterine development. Toward term, the maturational rise in fetal glucocorticoid receptor …

The whole-animal content of the cortisol was measured in embryos and larvae of tilapia
(Oreochromis mossambicus), rainbow trout (Oncorhynchus mykiss), ayu (Plecoglossus …

Glucocorticoids have an important role in development of the metabolic phenotype in utero.
They act as environmental and maturational signals in adapting feto-placental metabolism to …