Mechanisms of chemotherapy-induced peripheral neuropathy

R Zajączkowska, M Kocot-Kępska, W Leppert… - International journal of …, 2019 - mdpi.com
Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most frequent side
effects caused by antineoplastic agents, with a prevalence from 19% to over 85%. Clinically …

Neuroinflammatory process involved in different preclinical models of chemotherapy-induced peripheral neuropathy

G Fumagalli, L Monza, G Cavaletti, R Rigolio… - Frontiers in …, 2021 - frontiersin.org
Peripheral neuropathies are characterized by nerves damage and axonal loss, and they
could be classified in hereditary or acquired forms. Acquired peripheral neuropathies are …

Chemotherapy-induced peripheral neuropathy: part 1—current state of knowledge and perspectives for pharmacotherapy

K Sałat - Pharmacological reports, 2020 - Springer
Background Despite the increasing knowledge of the etiology of neuropathic pain, this type
of chronic pain is resistant to available analgesics in approximately 50% of patients and …

Targeting strategies for oxaliplatin-induced peripheral neuropathy: clinical syndrome, molecular basis, and drug development

Y Yang, B Zhao, X Gao, J Sun, J Ye, J Li… - Journal of experimental & …, 2021 - Springer
Oxaliplatin (OHP)-induced peripheral neurotoxicity (OIPN) is a severe clinical problem and
potentially permanent side effect of cancer treatment. For the management of OIPN, accurate …

[HTML][HTML] The effect of schwann cells/schwann cell-like cells on cell therapy for peripheral neuropathy

Q Wang, FY Chen, ZM Ling, WF Su, YY Zhao… - Frontiers in Cellular …, 2022 - frontiersin.org
Peripheral neuropathy is a common neurological issue that leads to sensory and motor
disorders. Over time, the treatment for peripheral neuropathy has primarily focused on …

A comparative review of chemotherapy-induced peripheral neuropathy in in vivo and in vitro models

S Eldridge, L Guo, J Hamre III - Toxicologic pathology, 2020 - journals.sagepub.com
Chemotherapy-induced peripheral neuropathy (CIPN) is an adverse effect caused by
several classes of widely used anticancer therapeutics. Chemotherapy-induced peripheral …

Recent developments of novel pharmacologic therapeutics for prevention of chemotherapy-induced peripheral neuropathy

S Hu, KM Huang, EJ Adams, CL Loprinzi… - Clinical Cancer …, 2019 - AACR
Chemotherapy-induced peripheral neuropathy (CIPN) is a common and dose-limiting
toxicity, negatively affecting both quality of life and disease outcomes. To date, there is no …

An updated understanding of the mechanisms involved in chemotherapy-induced neuropathy

JA Boyette-Davis, S Hou, S Abdi… - Pain management, 2018 - Taylor & Francis
The burdensome condition of chemotherapy-induced peripheral neuropathy occurs with
various chemotherapeutics, including bortezomib, oxaliplatin, paclitaxel and vincristine. The …

Pharmacologic management of persistent pain in cancer survivors

P Glare, K Aubrey, A Gulati, YC Lee, N Moryl… - Drugs, 2022 - Springer
Improvements in screening, diagnosis and treatment of cancer has seen cancer mortality
substantially diminish in the past three decades. It is estimated there are almost 20 million …

Pathogenesis of platinum-induced peripheral neurotoxicity: Insights from preclinical studies

A Calls, V Carozzi, X Navarro, L Monza, J Bruna - Experimental Neurology, 2020 - Elsevier
One of the most relevant dose-limiting adverse effects of platinum drugs is the development
of a sensory peripheral neuropathy that highly impairs the patients' quality of life. Nowadays …