Synthesis of heterocyclic compounds via Michael and Hantzsch reactions

AM Abdella, AM Abdelmoniem… - Journal of …, 2020 - Wiley Online Library
Heterocycles represent the largest diversity of organic compounds with signifcant chemical,
biomedical, and industrial applications. They exist in numerous natural products, dyes, and …

Novel 3-(pyrazol-4-yl)-2-(1H-indole-3-carbonyl)acrylonitrile derivatives induce intrinsic and extrinsic apoptotic death mediated P53 in HCT116 colon carcinoma

MF Mohamed, NS Ibrahim, AA Saddiq… - Scientific Reports, 2023 - nature.com
A novel series of α-cyano indolylchalcones was prepared, and their chemical structures
were confirmed based on the different spectral data. Among them, compound 7f was …

Novel diphenyl ether-heterocycles hybrids: Synthesis via Hantzsch and Biginelli reactions, molecular docking simulation, and antimicrobial activities

YA El-Gabry, ME Salem, NS Ibrahim… - Journal of Molecular …, 2024 - Elsevier
By reacting the potassium salt produced by treating 4-hydroxybenzaldehyde with ethanolic
KOH with 4-fluorobenzaldehyde in DMF at reflux, 4, 4′-oxydibenzaldehyde was produced …

Molecular docking simulation and anticancer assessment on human breast carcinoma cell line using novel bis (1, 4-dihydropyrano [2, 3-c] pyrazole-5-carbonitrile) and …

SK Salama, MF Mohamed, AF Darweesh… - Bioorganic …, 2017 - Elsevier
An efficient route for the synthesis of novel bis (1, 4-dihydropyrano [2, 3-c] pyrazole-5-
carbonitrile) derivatives is reported. The synthetic pathway involves one pot, synthesis of bis …

Synthesis and Anti‐influenza Virus Activity of Novel bis(4H‐chromene‐3‐carbonitrile) Derivatives

AM Abdella, Y Moatasim, MA Ali… - Journal of …, 2017 - Wiley Online Library
An efficient and convenient method for the synthesis of bis (4H‐chromene‐3‐carbonitrile)
derivatives by one‐pot, multicomponent reaction of bis‐aldehydes, malononitrile, and …

Synthesis of novel bis (spirocyclic-2-oxindole)-tethered 10b-azachrysene or 10a-azaphenanthrene systems via a Hantzsch-like reaction

AM Abdelmoniem, IA Abdelhamid, AHM Elwahy… - Tetrahedron, 2024 - Elsevier
The effective synthesis of bis (spirocyclic-2-oxindole) tethered to 10b-azachrysene or 10a-
azaphenanthrene moieties via the Hantzsch-like reaction of phenylenebis (methylene)) bis …

Hantzsch‐like synthesis of isoquinolino[2,1‐a]quinoline‐12‐carbonitrile incorporating aryl or heteroaryl moieties at C‐13

MA Mohamed Teleb, HM Hassaneen… - Journal of …, 2024 - Wiley Online Library
The synthesis of a new series of the tetracyclic 13‐arylisoquinolino [2, 1‐a] quinoline‐12‐
carbonitrile has been accomplished using a straightforward and efficient method. The novel …

Novel thiazole-based cyanoacrylamide derivatives: DNA cleavage, DNA/BSA binding properties and their anticancer behaviour against colon and breast cancer cells

K Barakat, MA Ragheb, MH Soliman, AM Abdelmoniem… - BMC chemistry, 2024 - Springer
A novel series of 2-cyano-3-(pyrazol-4-yl)-N-(thiazol-2-yl) acrylamide derivatives (3a–f) were
synthesized using Knoevenagel condensation and characterized using various spectral …

Regioselective synthesis of fused pyrimidines and quinazolines linked to Phenoxy‐N‐arylacetamide moieties as novel hybrid molecules via Biginelli‐like reaction

AM Abdelmoniem, RE Abdelwahab… - Journal of …, 2023 - Wiley Online Library
A novel series of 6‐acetyl‐[1, 2, 4] triazolo [1, 5‐a] pyrimidines, hexahydro‐[1, 2, 4] triazolo
[5, 1‐b] quinazolines, tetrahydrobenzo [4, 5] imidazo [2, 1‐b] quinazolin‐1‐ones, and 3 …

Synthesis, cytotoxicity, anti-inflammatory, anti-metastatic and anti-oxidant activities of novel chalcones incorporating 2-phenoxy-N-arylacetamide and thiophene …

NS Ibrahim, HA Sayed, M Sharaky, HM Diab… - Naunyn-Schmiedeberg's …, 2024 - Springer
Eight Novel chalcones were synthesized and their structures were confirmed by different
spectral tools. All the prepared compounds were subjected to SRB cytotoxic screening …