Chemokines are a family of small, secreted cytokines which regulate a variety of cell
functions. The CXC motif chemokine ligand 12 (CXCL12) binds to CXC chemokine receptor …

The tumour microenvironment is the primary location in which tumour cells and the host
immune system interact. Different immune cell subsets are recruited into the tumour …

Effective immunotherapy promotes the killing of cancer cells by cytotoxic T cells. This
requires not only that cancer-specific T cells be generated, but also that these T cells …

Immune checkpoint inhibition and chimeric antigen receptor (CAR) T cell therapy have
demonstrated stunning clinical efficacy in many cancer types. However, most patients do not …

The tumor microenvironment comprises a mass of heterogeneous cell types, including
immune cells, endothelial cells, and fibroblasts, alongside cancer cells. It is increasingly …

Increasing evidence indicates that the tumor microenvironment has critical roles in all
aspects of cancer biology, including growth, angiogenesis, metastasis and progression …

Solid tumors consist of neoplastic cells, non-malignant stromal cells, and migratory
hematopoietic cells. Complex interactions between the cell types in this microenvironment …

Chemotaxis of tumour cells and stromal cells in the surrounding microenvironment is an
essential component of tumour dissemination during progression and metastasis. This …

Chemokines govern leukocyte migration by attracting cells that express their cognate
ligands. Many cancer types show altered chemokine secretion profiles, favoring the …

Cancer cells possess a broad spectrum of migration and invasion mechanisms. These
include both individual and collective cell-migration strategies. Cancer therapeutics that are …