Biomarkers for sepsis: more than just fever and leukocytosis—a narrative review

T Barichello, JS Generoso, M Singer, F Dal-Pizzol - Critical Care, 2022 - Springer
A biomarker describes a measurable indicator of a patient's clinical condition that can be
measured accurately and reproducibly. Biomarkers offer utility for diagnosis, prognosis …

Arginine and citrulline and the immune response in sepsis

KAP Wijnands, TMR Castermans, MPJ Hommen… - Nutrients, 2015 - mdpi.com
Arginine, a semi-essential amino acid is an important initiator of the immune response.
Arginine serves as a precursor in several metabolic pathways in different organs. In the …

Biomarkers of gut barrier failure in the ICU

G Piton, G Capellier - Current opinion in critical care, 2016 - journals.lww.com
Enterocyte biomarkers may help the intensivist to identify patients presenting with intestinal
damage, and who are at risk of bacterial translocation and systemic inflammatory response …

Potential implications of citrulline and quercetin on gut functioning of monogastric animals and humans: a comprehensive review

VA Uyanga, FK Amevor, M Liu, Z Cui, X Zhao, H Lin - Nutrients, 2021 - mdpi.com
The importance of gut health in animal welfare and wellbeing is undisputable. The intestinal
microbiota plays an essential role in the metabolic, nutritional, physiological, and …

Citrulline, biomarker of enterocyte functional mass and dietary supplement. Metabolism, transport, and current evidence for clinical use

S Maric, T Restin, JL Muff, SM Camargo… - Nutrients, 2021 - mdpi.com
L-Citrulline is a non-essential but still important amino acid that is released from enterocytes.
Because plasma levels are reduced in case of impaired intestinal function, it has become a …

Cellular metabolism of myeloid cells in sepsis

RJW Arts, MS Gresnigt, LAB Joosten… - Journal of Leucocyte …, 2017 - academic.oup.com
In recent years, it has become appreciated that immune cells have different metabolic
profiles depending on their activation status. During sepsis, circulating leukocytes go …

Bench to bedside review: therapeutic modulation of nitric oxide in sepsis—an update

S Lambden - Intensive Care Medicine Experimental, 2019 - Springer
Nitric oxide is a signalling molecule with an extensive range of functions in both health and
disease. Discovered in the 1980s through work that earned the Nobel prize, nitric oxide is an …

Free amino acid composition of saliva in patients with healthy periodontium and periodontitis

N Balci, Ş Kurgan, A Çekici, T Çakır… - Clinical Oral Investigations, 2021 - Springer
Objectives To identify and compare the free amino acids in the saliva of periodontitis
patients and healthy individuals and to assess their levels in different periodontal disease …

Gastrointestinal failure in the ICU

A Reintam Blaser, SM Jakob… - Current opinion in critical …, 2016 - ingentaconnect.com
Purpose of review The current review summarizes different aspects of assessment of
gastrointestinal function and provides a practical approach to management of adult patients …

Citrulline, intestinal fatty acid-binding protein and the acute gastrointestinal injury score as predictors of gastrointestinal failure in patients with sepsis and septic shock

M Tyszko, A Lemańska-Perek, J Śmiechowicz… - Nutrients, 2023 - mdpi.com
Gastrointestinal (GI) failure can be both a cause of sepsis and a consequence of the
systemic pro-inflammatory response in sepsis. Changes in biomarkers of enterocyte …