Ras and Rho proteins are GTP-regulated molecular switches that control multiple signaling
pathways in eukaryotic cells. Ras was among the first identified oncogenes, and it appears …

Ras proteins are essential mediators of a multitude of cellular processes, and its
deregulation is frequently associated with cancer appearance, progression, and metastasis …

Transcriptomic imputation approaches combine eQTL reference panels with large-scale
genotype data in order to test associations between disease and gene expression. These …

The p53 gene is mutated in over half of all cancers, reflecting its critical role as a tumor
suppressor. Although p53 is a transcriptional activator that induces myriad target genes …

Reelin was originally identified as a regulator of neuronal migration and synaptic function,
but its non-neuronal functions have received far less attention. Reelin participates in organ …

Reelin is a large secreted glycoprotein that is essential for correct neuronal positioning
during neurodevelopment and is important for synaptic plasticity in the mature brain …

Phosphoinositide 3-kinases (PI3Ks) are lipid kinases essential for growth and metabolism.
Their aberrant activation is associated with many types of cancers. Here we used single …

The brain–gut axis, a bidirectional network between the central and enteric nervous system,
plays a critical role in modulating the gastrointestinal tract function and homeostasis …

Endogenous electric fields (EFs) are capable of regulating the behaviors of skin cells in
wound healing. However, majority of current dressings are primarily engaged in the passive …

The PI3K/AKT pathway is a key target in oncology where most efforts are focussed on
phenotypes such as cell proliferation and survival. Comparatively, little attention has been …