Estimated glomerular filtration rate (eGFR) impacts the concentration of plasma biomarkers
confounding biomarker association studies of eGFR with reverse causation. To identify …

Background Diabetic kidney disease (DKD) is responsible for close to half of all ESKD
cases. Although unbiased gene expression changes have been extensively characterized in …

Aims Chronic kidney disease (CKD) is widely prevalent and independently increases
cardiovascular risk. Cardiovascular risk prediction tools derived in the general population …

Background Due to the asymptomatic nature of the early stages, chronic kidney disease
(CKD) is usually diagnosed at late stages and lacks targeted therapy, highlighting the need …

Identifying circulating proteins associated with cognitive function may point to biomarkers
and molecular process of cognitive impairment. Few studies have investigated the …

Background: The TOPCAT trial (Treatment of Preserved Cardiac Function Heart Failure With
an Aldosterone Antagonist Trial) suggested clinical benefits of spironolactone treatment …

In the past years, we have witnessed a true explosion of omics data in the landscape of
kidney research. The proliferation and wide application of omics technologies offer insights …

Background Proteins and metabolites are essential for many biological functions and often
linked through enzymatic or transport reactions. Individual molecules have been associated …

Context Patients with younger onset of type 2 diabetes (YT2D) have increased risk for
kidney failure compared to those with late onset. However, the mechanism of diabetic kidney …

The kidney tubules constitute two-thirds of the cells of the kidney and account for the majority
of the organ's metabolic energy expenditure. Acute tubular injury (ATI) is observed across …