Exploring the Influence of Gut–Brain Axis Modulation on Cognitive Health: A Comprehensive Review of Prebiotics, Probiotics, and Symbiotics

M Fekete, A Lehoczki, D Major, V Fazekas-Pongor… - Nutrients, 2024 - mdpi.com
Recent research exploring the relationship between the gut and the brain suggests that the
condition of the gut microbiota can influence cognitive health. A well-balanced gut …

[HTML][HTML] The Hidden Dangers of Sedentary Living: Insights into Molecular, Cellular, and Systemic Mechanisms

DG Diniz, J Bento-Torres, VO da Costa… - International Journal of …, 2024 - mdpi.com
With the aging of the global population, neurodegenerative diseases are emerging as a
major public health issue. The adoption of a less sedentary lifestyle has been shown to have …

The fate of neuronal synapse homeostasis in aging, infection, and inflammation

C Tacke, P Landgraf, DC Dieterich… - American Journal of …, 2024 - journals.physiology.org
Neuroplasticity is the brain's ability to reorganize and modify its neuronal connections in
response to environmental stimuli, experiences, learning, and disease processes. This …

Dysregulated C1q and CD47 in the aging monkey brain: association with myelin damage, microglia reactivity, and cognitive decline

SA DeVries, C Dimovasili, M Medalla… - Frontiers in …, 2024 - frontiersin.org
Normal aging, though lacking widespread neurodegeneration, is nevertheless characterized
by cognitive impairment in learning, memory, and executive function. The aged brain is …

Long-term calorie restriction reduces oxidative DNA damage to oligodendroglia and promotes homeostatic microglia in the aging monkey brain

AT Vitantonio, C Dimovasili, F Mortazavi… - Neurobiology of …, 2024 - Elsevier
Calorie restriction (CR) is a robust intervention that can slow biological aging and extend
lifespan. In the brain, terminally differentiated neurons and glia accumulate oxidative …

TIA1 Mediates Divergent Inflammatory Responses to Tauopathy in Microglia and Macrophages

CJ Webber, S Van Der Spek, ALF Cruz, S Puri… - bioRxiv, 2024 - biorxiv.org
The RNA binding protein TIA1 is known to regulate stress responses. Here we show that
TIA1 plays a much broader role in inflammatory cells, being required for the microglial …

[PDF][PDF] Sedentary Life Is an Invisible Trap: Molecular, Cellular, and Systemic Reasons to Leave It Behind

DG Diniz, J Bento-Torres, VO Da Costa, JPR Carvalho… - 2024 - preprints.org
As the global population ages, the prevalence of neurodegenerative diseases has become
a major public health concern. The adoption of a less sedentary lifestyle has been shown to …

An Agent-Based Model of Microglia and Neuron Interaction: Implications in Neurodegenerative Disease

C Ty, A Case, E Mezzulo, A Penland… - Spora: A Journal of … - ir.library.illinoisstate.edu
Whether immune cells protect or harm the brain is an open question depending on context,
and their role is implicated in multiple diseases such as Alzheimer's disease, dementia, and …