Overcoming the physiological barriers in the eye remains a key obstacle in the field of ocular
drug delivery. While ocular barriers naturally have a protective function, they also limit drug …

Topical ocular drug delivery has been considered to be an ideal route of administration for
treatment of ocular diseases related to the anterior segment of the eye. However, topical …

Transdermal drug delivery (TDD) is limited by the outer layer of the skin, ie, the stratum
corneum. Research on TDD has become very active in the recent years and various …

Objective The basic concepts, major mechanisms, technological developments and
advantages of the topical application of lipid-based systems (microemulsions …

Background Degenerative ocular diseases such as macular retinopathy and retinal
disorders significantly affect vision loss and the quality of life. The prevalence of these …

This study employed superficial ultrasound exposure of good ocular safety and a drug-
loaded hydrogel of long residence time to enable transscleral delivery. First, we designed an …

This study was designed to investigate the feasibility of silk fibroin nanoparticles (SFNs) for
sustained drug delivery in transscleral ultrasound. Fluorescein isothiocynate labeled bovine …

Silk is a wonderful biopolymer that has a long history of medical applications. Surgical cords
and medically authorised human analogues made of silk have a long history of use in …

Intravitreal injection is the most common administration route for the treatment of retinal
diseases. However, the vitreous and some of the retinal layers themselves act as significant …

In this review, we present current state-of-the-art developments and challenges in the areas
of thermal therapy, ultrasound tomography, image-guided therapies, ocular drug delivery …