The therapeutic importance of acid-base balance

BN Quade, MD Parker, R Occhipinti - Biochemical pharmacology, 2021 - Elsevier
Baking soda and vinegar have been used as home remedies for generations and today we
are only a mouse-click away from claims that baking soda, lemon juice, and apple cider …

Action mode of gut motility, fluid and electrolyte transport in chronic constipation

Q Zhao, YY Chen, DQ Xu, SJ Yue, RJ Fu… - Frontiers in …, 2021 - frontiersin.org
Chronic constipation is a common gastrointestinal disorder, with a worldwide incidence of
14–30%. It negatively affects quality of life and is associated with a considerable economic …

Chitosan oligosaccharides attenuate loperamide-induced constipation through regulation of gut microbiota in mice

X Zhang, H Yang, J Zheng, N Jiang, G Sun, X Bao… - Carbohydrate …, 2021 - Elsevier
This study was designed to explore the improvement of chitosan oligosaccharides (COS) on
constipation through regulation of gut microbiota. Here, we proved that COS treatment …

Application of transcriptome analysis: Oxidative stress, inflammation and microtubule activity disorder caused by ammonia exposure may be the primary factors of …

S Wang, X Li, W Wang, H Zhang, S Xu - Science of the Total Environment, 2019 - Elsevier
Abstract Ammonia (NH 3), an inhaled harmful gas, is not only an important volatile in
fertilizer production and ranching, but also the main basic component of haze. However, the …

Construction of a novel choline metabolism-related signature to predict prognosis, immune landscape, and chemotherapy response in colon adenocarcinoma

C Liu, D Liu, F Wang, Y Liu, J Xie, J Xie… - Frontiers in …, 2022 - frontiersin.org
Background Colon adenocarcinoma (COAD) is a common digestive system malignancy with
high mortality and poor prognosis. Accumulating evidence indicates that choline metabolism …

Chronic constipation: new insights, better outcomes?

LR Schiller - The lancet Gastroenterology & hepatology, 2019 - thelancet.com
Constipation is a symptom that affects around 11–20% of the adult population yearly. Most
physicians consider infrequency of defecation as a hallmark of constipation. However, most …

Fluid shear stress enhances differentiation of jejunal human enteroids in Intestine-Chip

J Yin, L Sunuwar, M Kasendra, H Yu… - American Journal …, 2021 - journals.physiology.org
There is increasing evidence that the study of normal human enteroids duplicates many
known aspects of human intestinal physiology. However, this epithelial cell-only model lacks …

Chloride transport modulators as drug candidates

AS Verkman, LJV Galietta - American Journal of Physiology …, 2021 - journals.physiology.org
Chloride transport across cell membranes is broadly involved in epithelial fluid transport, cell
volume and pH regulation, muscle contraction, membrane excitability, and organellar …

[HTML][HTML] Small-molecule inhibitor of intestinal anion exchanger SLC26A3 for treatment of hyperoxaluria and nephrolithiasis

O Cil, T Chu, S Lee, PM Haggie, AS Verkman - JCI insight, 2022 - ncbi.nlm.nih.gov
Nephrolithiasis is a common and recurrent disease affecting 9% of the US population.
Hyperoxaluria is major risk factor for calcium oxalate kidney stones, which constitute two …

Small molecule inhibitors of intestinal epithelial anion exchanger SLC26A3 (DRA) with a luminal, extracellular site of action

O Cil, MO Anderson, L de Souza Goncalves… - European journal of …, 2023 - Elsevier
The anion exchanger protein SLC26A3 (down-regulated in adenoma, DRA) is expressed in
the luminal membrane of intestinal epithelial cells in colon, where it facilitates the absorption …