Diabetic macular edema: current understanding, molecular mechanisms and therapeutic implications

J Zhang, J Zhang, C Zhang, J Zhang, L Gu, D Luo… - Cells, 2022 - mdpi.com
Diabetic retinopathy (DR), with increasing incidence, is the major cause of vision loss and
blindness worldwide in working-age adults. Diabetic macular edema (DME) remains the …

VEGF-targeting drugs for the treatment of retinal neovascularization in diabetic retinopathy

A Arrigo, E Aragona, F Bandello - Annals of medicine, 2022 - Taylor & Francis
Diabetic retinopathy (DR) is the most common microangiopathic complication of diabetes
mellitus, representing a major cause of visual impairment in developed countries …

Diabetic retinopathy preferred practice pattern®

CJ Flaxel, RA Adelman, ST Bailey, A Fawzi, JI Lim… - …, 2020 - aaojournal.org
Background: Diabetic retinopathy is a leading cause of visual impairment in working-age
adults worldwide. Duration of diabetes is a major risk factor associated with the development …

Aflibercept, bevacizumab, or ranibizumab for diabetic macular edema.

JA Wells, AR Glassman, AR Ayala… - The New England …, 2015 - europepmc.org
Background The relative efficacy and safety of intravitreous aflibercept, bevacizumab, and
ranibizumab in the treatment of diabetic macular edema are unknown. Methods At 89 …

Diabetic macular edema: pathophysiology and novel therapeutic targets

A Das, PG McGuire, S Rangasamy - Ophthalmology, 2015 - Elsevier
Diabetic macular edema (DME) is the major cause of vision loss in diabetic persons.
Alteration of the blood–retinal barrier is the hallmark of this disease, characterized by …

Diabetic macular edema: evidence-based management

DJ Browning, MW Stewart, C Lee - Indian journal of …, 2018 - journals.lww.com
Diabetic macular edema (DME) is the most common cause of vision loss in patients with
diabetic retinopathy with an increasing prevalence tied to the global epidemic in type 2 …

Systemic pharmacokinetics and pharmacodynamics of intravitreal aflibercept, bevacizumab, and ranibizumab

RL Avery, AA Castellarin, NC Steinle, DS Dhoot… - Retina, 2017 - journals.lww.com
Purpose: To evaluate the systemic pharmacokinetics (PKs) of aflibercept, bevacizumab, and
ranibizumab in patients with neovascular age-related macular degeneration (AMD), diabetic …

[HTML][HTML] Ocular complications of diabetes mellitus

N Sayin, N Kara, G Pekel - World journal of diabetes, 2015 - ncbi.nlm.nih.gov
Diabetes mellitus (DM) is a important health problem that induces ernestful complications
and it causes significant morbidity owing to specific microvascular complications such as …

Intravitreal aflibercept for diabetic macular edema: 100-week results from the VISTA and VIVID studies

DM Brown, U Schmidt-Erfurth, DV Do, FG Holz… - Ophthalmology, 2015 - Elsevier
Purpose To compare efficacy and safety of 2 dosing regimens of intravitreal aflibercept
injection (IAI) with macular laser photocoagulation for diabetic macular edema (DME) …

OCT biomarkers as functional outcome predictors in diabetic macular edema treated with dexamethasone implant

D Zur, M Iglicki, C Busch, A Invernizzi, M Mariussi… - Ophthalmology, 2018 - Elsevier
Purpose Identification and characterization of patients with diabetic macular edema (DME)
are important for individualizing treatment and optimizing outcome. We investigated OCT …