Inhibitors of protein methyltransferases and demethylases
Post-translational modifications of histones by protein methyltransferases (PMTs) and
histone demethylases (KDMs) play an important role in the regulation of gene expression …
histone demethylases (KDMs) play an important role in the regulation of gene expression …
Lysine demethylase KDM6A in differentiation, development, and cancer
ABSTRACT Lysine demethylase 6A (KDM6A), also known as UTX, belongs to the KDM6
family of histone H3 lysine 27 (H3K27) demethylases, which also includes UTY and KDM6B …
family of histone H3 lysine 27 (H3K27) demethylases, which also includes UTY and KDM6B …
Protein post-translational modifications and regulation of pluripotency in human stem cells
Post-translational modifications (PTMs) are known to be essential mechanisms used by
eukaryotic cells to diversify their protein functions and dynamically coordinate their signaling …
eukaryotic cells to diversify their protein functions and dynamically coordinate their signaling …
Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia
P Ntziachristos, A Tsirigos, GG Welstead, T Trimarchi… - Nature, 2014 - nature.com
T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy with a dismal
overall prognosis, including a relapse rate of up to 25%, mainly because of the lack of non …
overall prognosis, including a relapse rate of up to 25%, mainly because of the lack of non …
[HTML][HTML] Understanding intrinsic hematopoietic stem cell aging
E Mejia-Ramirez, MC Florian - haematologica, 2020 - ncbi.nlm.nih.gov
Hematopoietic stem cells (HSC) sustain blood production over the entire life-span of an
organism. It is of extreme importance that these cells maintain self-renewal and …
organism. It is of extreme importance that these cells maintain self-renewal and …
Mutation Update for Kabuki Syndrome Genes KMT2D and KDM6A and Further Delineation of X‐Linked Kabuki Syndrome Subtype 2
N Bögershausen, V Gatinois, V Riehmer… - Human …, 2016 - Wiley Online Library
Kabuki syndrome (KS) is a rare but recognizable condition that consists of a characteristic
face, short stature, various organ malformations, and a variable degree of intellectual …
face, short stature, various organ malformations, and a variable degree of intellectual …
UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs
M Gozdecka, E Meduri, M Mazan, K Tzelepis… - Nature …, 2018 - nature.com
The histone H3 Lys27-specific demethylase UTX (or KDM6A) is targeted by loss-of-function
mutations in multiple cancers. Here, we demonstrate that UTX suppresses myeloid …
mutations in multiple cancers. Here, we demonstrate that UTX suppresses myeloid …
Driver mutations of cancer epigenomes
Epigenetic alterations are associated with all aspects of cancer, from tumor initiation to
cancer progression and metastasis. It is now well understood that both losses and gains of …
cancer progression and metastasis. It is now well understood that both losses and gains of …
[HTML][HTML] Genome-wide association studies of human and rat BMI converge on synapse, epigenome, and hormone signaling networks
A vexing observation in genome-wide association studies (GWASs) is that parallel analyses
in different species may not identify orthologous genes. Here, we demonstrate that cross …
in different species may not identify orthologous genes. Here, we demonstrate that cross …
Molecular and cellular mechanisms of aging in hematopoietic stem cells and their niches
L Zhang, R Mack, P Breslin, J Zhang - Journal of Hematology & Oncology, 2020 - Springer
Aging drives the genetic and epigenetic changes that result in a decline in hematopoietic
stem cell (HSC) functioning. Such changes lead to aging-related hematopoietic/immune …
stem cell (HSC) functioning. Such changes lead to aging-related hematopoietic/immune …