Vaccination is an excellent strategy to limit the morbidity and mortality associated with
infectious disease. Vaccination creates protective, long-lived antibody-mediated immunity by …

Follicular helper T (Tfh) cells have been implicated in controlling rejection after allogeneic
kidney transplantation, but the precise subsets, origins, and functions of Tfh cells in this …

Coronavirus disease 2019 (COVID-19) has been a global pandemic, caused by a novel
coronavirus strain with strong infectivity, severe acute respiratory syndrome coronavirus 2 …

SARS-CoV-2 variants and seasonal coronaviruses continue to cause disease and
coronaviruses in the animal reservoir pose a constant spillover threat. Importantly …

T cell help is a crucial component of the normal humoral immune response, yet whether it
promotes or restrains autoreactive B cell responses remains unclear. Here, we observe that …

Follicular regulatory T cells (Tfr) restrict development of autoantibodies and autoimmunity
while supporting high-affinity foreign antigen-specific humoral response. However, whether …

A variety of B cell clones seed the germinal centers, where a selection stringency expands
the fitter clones to generate higher affinity antibodies. However, recent experiments suggest …

Heterologous prime-boost has broken the protective immune response bottleneck of the
COVID-19 vaccines. however, the underlying mechanisms have not been fully elucidated …

Current influenza vaccine strategies have yet to overcome significant obstacles, including
rapid antigenic drift of seasonal influenza viruses, in generating efficacious long-term …

The ongoing evolution and emergence of SARS-CoV-2 variants have raised concerns
regarding the efficacy of existing vaccines and therapeutic agents. This study aimed to …