Curative cancer therapy remains a major challenge particularly in cancers displaying
multidrug resistance (MDR). The MDR phenotype is characterized by cross-resistance to a …

Background Lung cancer is the most commonly diagnosed cancer and the leading cause of
cancer death in both sexes worldwide. Approximately 50% of those diagnosed with lung …

Background The highly refractory nature of non-small cell lung cancer (NSCLC) to
chemotherapeutic drugs is an important factor resulting in its poor prognosis. Recent studies …

Despite improvements in the therapeutic approaches for hematological malignancies in the
last decades, refractory disease still occurs, and cancer drug resistance still remains a major …

Bladder cancer (BCa) is burdened by high rates of chemo-and radio-resistance. We
reviewed and summarized the current evidence regarding the genetic determinants of …

The mitotic phase is a vital step in cell division and may be involved in cancer progression,
but it remains unclear whether genetic variants in mitotic phase‐related pathways genes …

Introduction: The efficacy of platinum-based chemotherapy for patients with non-small cell
lung cancer (NSCLC) is limited by chemoresistance. Platinum drugs damage DNA by …

Platinum‐based chemotherapy is regarded as a preferential curative‐intent option for non‐
small cell lung cancer (NSCLC), while the acquired drug resistance has become a major …

Lung cancer, the leading cause of death worldwide, arises from an intricate combination of
genetic and environmental factors. Genetic variations can influence the chemotherapeutic …

Background: The E3 ubiquitin ligase neural precursor cell expressed developmentally
downregulated 4-1 (NEDD4-1) negatively regulates phosphatase and tensin homolog …