Fifty years after the recognition of the Li–Fraumeni syndrome (LFS), our perception of
cancers related to germline alterations of TP53 has drastically changed:(i) germline TP53 …

Whole-body magnetic resonance imaging (WB-MRI) is currently recommended for cancer
screening in adult and paediatric subjects with cancer predisposition syndromes …

OBJECTIVE. Li-Fraumeni syndrome (LFS) is a rare autosomal-dominant inherited syndrome
containing a germline mutation in the TP53 gene, which predisposes to oncogenesis …

Li–Fraumeni syndrome (LFS) is a hereditary tumor that exhibits autosomal dominant
inheritance. LFS develops in individuals with a pathogenic germline variant of the cancer …

Simple Summary TP53 variants detected in blood represent a main genetic cause of breast
cancers occurring before 31 years of age. TP53 being included in most of the cancer gene …

Introduction Patients with germline TP53 pathogenic variants (Li–Fraumeni syndrome LFS)
are at extremely high lifetime risk of developing cancer. Recent data suggest that tumor …

Li-Fraumeni syndrome (LFS) is a rare hereditary cancer syndrome associated with an
autosomal-dominant mutation inheritance in the TP53 tumor suppressor gene and a wide …

Abstract Li-Fraumeni Syndrome (LFS) is a hereditary cancer predisposition syndrome with
up to 90% lifetime cancer risk. Cancer screening, including annual whole-body MRI (WB …

Summary Background In Brazil, there is a higher prevalence of Li-Fraumeni Syndrome (LFS)
compared to worldwide, due to the founder mutation in the TP53 gene p. R337H. However …

Pediatric patients with cancer predisposition syndromes are at increased risk of developing
malignancies compared with their age-matched peers, necessitating regular surveillance …