The rising emergence of antibiotic resistance urges the search for new strategies to defeat
microorganisms that lead to persistent infections of the host. Tolerant to antibiotics, slowly …

Antibiotics are the cornerstone of modern medicine and agriculture, and rising antibiotic
resistance is one the biggest threats to global health and food security. Identifying new and …

The current SARS-CoV-2 pandemic and the likelihood that new coronavirus strains will
emerge in the immediate future point out the urgent need to identify new pan-coronavirus …

The importance of taking into account protein flexibility in drug design and virtual ligand
screening (VS) has been widely debated in the literature, and molecular dynamics (MD) has …

The last step of cysteine biosynthesis in bacteria and plants is catalyzed by O-acetylserine
sulfhydrylase. In bacteria, two isozymes, O-acetylserine sulfhydrylase-A and O-acetylserine …

The physical organization of enzymes in metabolism is an old concept being revisited by
new experimental approaches. In plants and microbes, the enzymes of cysteine …

Human serine racemase is a pyridoxal 5′-phosphate (PLP)-dependent dimeric enzyme
that catalyzes the reversible racemization of L-serine and D-serine and their dehydration to …

The cysteine biosynthetic pathway is absent in humans but essential in microbial pathogens,
suggesting that it provides potential targets for the development of novel antibacterial …

O-acetylserine sulfhydrylase A (CysK) is the pyridoxal 5′-phosphate-dependent enzyme
that catalyzes the final reaction of cysteine biosynthesis in bacteria. CysK was initially …

In ϒ-proteobacteria and Actinomycetales, cysteine biosynthetic enzymes are indispensable
during persistence and become dispensable during growth or acute infection. The …