The Wnt pathway is central to a host of developmental and disease-related processes. The
remarkable conservation of this intercellular signaling cascade throughout metazoan …

Congenital heart disease (CHD) is one of the most common birth defects. Studies in animal
models and humans have indicated a genetic etiology for CHD. About 400 genes have been …

Time-restricted feeding (TRF) improves metabolism independent of dietary macronutrient
composition or energy restriction. To elucidate mechanisms underpinning the effects of short …

Wnt signaling is an evolutionarily conserved metazoan cell communication pathway
required for proper animal development. Of the myriad of signaling events that have been …

Abstract β‐catenin‐mediated Wnt signaling is an ancient cell‐communication pathway in
which β‐catenin drives the expression of certain genes as a consequence of the trigger …

The WNT/β‐catenin pathway is a master regulator of cardiac development and growth, and
its activity is low in healthy adult hearts. However, even this low activity is essential for …

Upon WNT/β-catenin pathway activation, stabilized β-catenin travels to the nucleus where it
associates with the TCF/LEF transcription factors, constitutively bound to genomic Wnt …

Canonical Wnt/β-catenin signaling is an established regulator of cellular state and its critical
contributions to tumor initiation, malignant tumor progression and metastasis formation have …

Wnt signaling orchestrates gene expression via its effector, β-catenin. However, it is
unknown whether β-catenin binds its target genomic regions simultaneously and how this …

BCL9 and PYGO are β-catenin cofactors that enhance the transcription of Wnt target genes.
They have been proposed as therapeutic targets to diminish Wnt signaling output in …