BACKGROUND Alzheimer's disease (AD) and Parkinson's disease (PD) are the most
common human neurodegenerative diseases. AD is primarily a dementing disease, and PD …

Prions cause transmissible and genetic neurodegenerative diseases, including scrapie and
bovine spongiform encephalopathy of animals and Creutzfeldt-Jakob and Gerstmann …

Prion diseases are transmissible neurodegenerative disorders affecting both humans and
animals. The cellular prion protein, PrP C, and the abnormal infectious form, PrP Sc, are …

The discovery of infectious proteins, denoted prions, was unexpected. After much debate
over the chemical basis of heredity, resolution of this issue began with the discovery that …

▪ Abstract Prion diseases are transmissible neurodegenerative conditions that include
Creutzfeldt-Jakob disease (CJD) in humans and bovine spongiform encephalopathy (BSE) …

Recent research has established clear connections between G‐quadruplexes and human
disease. Features of quadruplex structures that promote genomic instability have been …

THE human prion diseases, Creutzfeldt–Jakob disease (CJD) and Gerstmann–Sträussler
syndrome (GSS), are neurodegenerative diseases that are unique in being both infectious …

Certain disease states are characterized by disturbances in production, accumulation or
clearance of protein. In Alzheimer disease, accumulation of amyloid-β (Aβ) in the brain and …

The molecular basis of strain variation in scrapie diseases is unknown. The only identified
component of the agent is the posttranslationally modified host prion protein (PrPSc). The …

GERSTMANN–Sträussler syndrome is a rare familial neuro-degenerative condition that is
vertically transmitted, in an apparently autosomal dominant way1. It can also be horizontally …