Ca2+ plays a crucial role in connecting membrane excitability with contraction in
myocardium. The hallmark features of heart failure are mechanical dysfunction and …

Understanding relationships between heart failure and arrhythmias, important causes of
suffering and sudden death, remains an unmet goal for biomedical researchers and …

Background—Hypertrophic cardiomyopathy (HCM), the most common mendelian heart
disorder, remains an orphan of disease-specific pharmacological treatment because of the …

Objectives: This study sought to examine the efficacy of ranolazine versus placebo on
weekly angina frequency and sublingual nitroglycerin use in subjects with type 2 diabetes …

Abstract Cardiomyocyte Na+ and Ca 2+ mishandling, upregulated Ca 2+/calmodulin-
dependent kinase II (CaMKII), and increased reactive oxygen species (ROS) are …

Abstract Nav1. 5, the pore forming α-subunit of the voltage-dependent cardiac Na+ channel,
is an integral membrane protein involved in the initiation and conduction of action potentials …

Over the last two decades, an increasing number of SCN5A mutations have been described
in patients with long QT syndrome type 3 (LQT3), Brugada syndrome,(progressive) …

Inhibition of cardiac late sodium current (late INa) is a strategy to suppress arrhythmias and
sodium-dependent calcium overload associated with myocardial ischemia and heart failure …

To date, no compounds or interventions exist that treat or prevent sarcomeric
cardiomyopathies. Established therapies currently improve the outcome, but novel therapies …

Influx of sodium ions through voltage-gated sodium channels in cardiomyocytes is essential
for proper electrical conduction within the heart. Both acquired conditions associated with …