Therapeutically harnessing extracellular vesicles

L Cheng, AF Hill - Nature Reviews Drug Discovery, 2022 - nature.com
The field of extracellular vesicle (EV) research has developed rapidly over the last decade
from the study of fundamental biology to a subject of significant clinical relevance. The …

Inhibiting extracellular vesicles formation and release: a review of EV inhibitors

M Catalano, L O'Driscoll - Journal of extracellular vesicles, 2020 - Taylor & Francis
It is now becoming well established that vesicles are released from a broad range of cell
types and are involved in cell-to-cell communication, both in physiological and pathological …

Endothelial responses in sepsis

J Joffre, J Hellman, C Ince… - American journal of …, 2020 - atsjournals.org
Endothelial cells (ECs) are vascular, nonconventional immune cells that play a major role in
the systemic response after bacterial infection to limit its dissemination. Triggered by …

Shedding light on the cell biology of extracellular vesicles

G Van Niel, G d'Angelo, G Raposo - Nature reviews Molecular cell …, 2018 - nature.com
Extracellular vesicles are a heterogeneous group of cell-derived membranous structures
comprising exosomes and microvesicles, which originate from the endosomal system or …

Guidelines for the use of flow cytometry and cell sorting in immunological studies

A Cossarizza, HD Chang, A Radbruch… - European journal of …, 2019 - Wiley Online Library
These guidelines are a consensus work of a considerable number of members of the
immunology and flow cytometry community. They provide the theory and key practical …

Exosomal PD-L1 promotes tumor growth through immune escape in non-small cell lung cancer

DH Kim, HR Kim, YJ Choi, SY Kim, JE Lee… - … & molecular medicine, 2019 - nature.com
Programmed cell death protein-1/programmed cell death ligand-1 (PD-1/PD-L1) pathway
blockade is a promising new cancer therapy. Although PD-1/PD-L1 treatment has yielded …

Sickle cell disease

GJ Kato, FB Piel, CD Reid, MH Gaston… - Nature reviews Disease …, 2018 - nature.com
Sickle cell disease (SCD) is a group of inherited disorders caused by mutations in HBB,
which encodes haemoglobin subunit β. The incidence is estimated to be between 300,000 …

Methodological guidelines to study extracellular vesicles

FAW Coumans, AR Brisson, EI Buzas… - Circulation …, 2017 - Am Heart Assoc
Owing to the relationship between extracellular vesicles (EVs) and physiological and
pathological conditions, the interest in EVs is exponentially growing. EVs hold high hopes …

[HTML][HTML] Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges

D Ha, N Yang, V Nadithe - Acta Pharmaceutica Sinica B, 2016 - Elsevier
Exosomes are small intracellular membrane-based vesicles with different compositions that
are involved in several biological and pathological processes. The exploitation of exosomes …

The methods of choice for extracellular vesicles (EVs) characterization

R Szatanek, M Baj-Krzyworzeka, J Zimoch… - International journal of …, 2017 - mdpi.com
In recent years, extracellular vesicles (EVs) have become a subject of intense study. These
membrane-enclosed spherical structures are secreted by almost every cell type and are …