BACE1 inhibitors: Current status and future directions in treating Alzheimer's disease

NM Moussa‐Pacha, SM Abdin, HA Omar… - Medicinal research …, 2020 - Wiley Online Library
Alzheimer's disease (AD) is an irreversible, progressive neurodegenerative brain disorder
with no current cure. One of the important therapeutic approaches of AD is the inhibition of β …

Neuroprotective natural products for Alzheimer's disease

X Chen, J Drew, W Berney, W Lei - Cells, 2021 - mdpi.com
Alzheimer's disease (AD) is the number one neurovegetative disease, but its treatment
options are relatively few and ineffective. In efforts to discover new strategies for AD therapy …

[HTML][HTML] Anti-psoriatic and anti-inflammatory effects of Kaempferia parviflora in keratinocytes and macrophage cells

MN Takuathung, S Potikanond, S Sookkhee… - Biomedicine & …, 2021 - Elsevier
Kaempferia parviflora (KP) has been used as folk medicine for curing various conditions,
including anti-inflammatory diseases. However, anti-psoriatic effects in an aspect of …

Kaempferia parviflora and Its Methoxyflavones: Chemistry and Biological Activities

D Chen, H Li, W Li, S Feng… - … Based Complementary and …, 2018 - Wiley Online Library
Kaempferia parviflora (KP), a health‐promoting herb, has been traditionally used for treating
a variety of diseases. Pharmacological studies have claimed the various benefits from KP …

Skin Rejuvenation Efficacy and Safety Evaluation of Kaempferia parviflora Standardized Extract (BG100) in Human 3D Skin Models and Clinical Trial

W Klinngam, P Rungkamoltip, R Wongwanakul… - Biomolecules, 2024 - mdpi.com
Polymethoxyflavones from Kaempferia parviflora rhizomes have been shown to effectively
combat aging in skin cells and tissues by inhibiting senescence, reducing oxidative stress …

Natural products targeting amyloid beta in Alzheimer's disease

JH Lee, NH Ahn, SB Choi, Y Kwon… - International journal of …, 2021 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disease characterized by severe brain
damage and dementia. There are currently few therapeutics to treat this disease, and they …

[HTML][HTML] Natural sources, refined extraction, biosynthesis, metabolism, and bioactivities of dietary polymethoxyflavones (PMFs)

R Gan, Y Liu, H Li, Y Xia, H Guo, F Geng… - Food Science and …, 2024 - Elsevier
Polymethoxyflavones (PMFs) are a type of uncommon dietary flavonoids, characterized by
more than one methoxy group, which exist in limited plant species, like Citrus species and …

Anti-Alzheimer's disease activity of compounds from the root bark of Morus alba L.

EB Kuk, AR Jo, SI Oh, HS Sohn, SH Seong… - Archives of pharmacal …, 2017 - Springer
The inhibition of acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and β-site
amyloid precursor protein cleaving enzyme 1 (BACE1) plays important roles in prevention …

Protective Effect of Polymethoxyflavones Isolated from Kaempferia parviflora against TNF-α-Induced Human Dermal Fibroblast Damage

HM Phung, S Lee, S Hong, S Lee, K Jung, KS Kang - Antioxidants, 2021 - mdpi.com
Similar to other organs, the skin undergoes a natural aging process. Moreover, constant
direct exposure to environmental stresses, including ultraviolet irradiation, causes the signs …

Demethylation of Polymethoxyflavones by Human Gut Bacterium, Blautia sp. MRG-PMF1

S Burapan, M Kim, J Han - Journal of Agricultural and Food …, 2017 - ACS Publications
Polymethoxyflavones (PMFs) were biotransformed to various demethylated metabolites in
the human intestine by the PMF-metabolizing bacterium, Blautia sp. MRG-PMF1. Because …