Conspectus Steroids continue to play a significant role in organic chemistry, medicinal
chemistry, and drug discovery due to their important biological activities and diverse …

A domino reaction has been defined by Tietze as a reaction involving two or more bond-
forming transformations that take place under the same reaction conditions, without adding …

Covering: 2008–2010 This report describes the recent applications of hypervalent iodine
reagents in the total synthesis of natural products. The large diversity of high-yielding and …

Here, we report on a scalable route to the polyhydroxylated steroid ouabagenin with an
unusual take on the age-old practice of steroid semisynthesis. The incorporation of both …

One of the largest classes of naturally occurring bioactive compounds, the terpenoids, is of
extraordinary pharmacological importance. 1, 2 The sphere of activity of terpenoids covers …

Modern organic synthesis focuses on the discovery and the development of stereoselective
multiple bond-forming transformations allowing the creation of several covalent bonds in a …

Conspectus Steroids, termed “keys to life” by Rupert Witzmann, have a wide variety of
biological activities, including anti-inflammatory, antishock, immunosuppressive, stress …

Highly oxygenated cardiotonic steroids, such as ouabain, possess a wide spectrum of
biological functions and remain significant synthetic challenges. Herein, we have applied an …

The natural product ouabagenin is a complex cardiotonic steroid with a highly oxygenated
skeleton. This full account describes the development of a concise synthesis of ouabagenin …

Aplysiasecosterol A (1) is a structurally unusual 9, 11-secosteroid isolated from the sea hare
Aplysia kurodai. We have accomplished the first and asymmetric total synthesis of 1 in a …