[HTML][HTML] An evaluation on potential anti-oxidant and anti-inflammatory effects of Crocin

S Bastani, V Vahedian, M Rashidi, A Mir… - Biomedicine & …, 2022 - Elsevier
Crocin, an active ingredient derived from saffron, is one of the herbal components that has
recently been considered by researchers. Crocin has been shown to have many anti …

Crocin molecular signaling pathways at a glance: A comprehensive review

M Boozari, H Hosseinzadeh - Phytotherapy Research, 2022 - Wiley Online Library
Crocin is a hydrophilic carotenoid that is synthesized in the flowers of the Crocus genus.
Numerous in vitro and in vivo research projects have been published about the biological …

Crocin inhibits angiogenesis and metastasis in colon cancer via TNF-α/NF-kB/VEGF pathways

HA Bakshi, GA Quinn, MM Nasef, V Mishra… - Cells, 2022 - mdpi.com
Angiogenesis and metastasis play pivotal roles in the progression of cancer. We recently
discovered that crocin, a dietary carotenoid derived from the Himalayan crocus, inhibited the …

Therapeutic effects of crocin alone or in combination with sorafenib against hepatocellular carcinoma: in vivo & in vitro insights

S Abdu, N Juaid, A Amin, M Moulay, N Miled - Antioxidants, 2022 - mdpi.com
This study investigated the therapeutic effects of the phytochemical crocin alone or in
combination with sorafenib both in rats chemically induced with hepatocellular carcinoma …

Metformin inhibits melanoma cell metastasis by suppressing the miR-5100/SPINK5/STAT3 axis

D Suwei, X Yanbin, W Jianqiang, M Xiang… - Cellular & Molecular …, 2022 - Springer
Melanoma is the most lethal skin cancer characterized by its high metastatic potential. It is
urgent to find novel therapy strategies to overcome this feature. Metformin has been …

Insulin and cancer: a tangled web

BP Leitner, S Siebel, ND Akingbesote… - Biochemical …, 2022 - portlandpress.com
For a century, since the pioneering work of Otto Warburg, the interwoven relationship
between metabolism and cancer has been appreciated. More recently, with obesity rates …

[HTML][HTML] The Antitumour Mechanisms of Carotenoids: A Comprehensive Review

A Baeza-Morales, M Medina-García… - Antioxidants, 2024 - mdpi.com
Carotenoids, known for their antioxidant properties, have garnered significant attention for
their potential antitumour activities. This comprehensive review aims to elucidate the diverse …

Metformin counteracts stimulatory effects induced by insulin in primary breast cancer cells

D Scordamaglia, F Cirillo, M Talia, MF Santolla… - Journal of Translational …, 2022 - Springer
Background Metabolic disorders are associated with increased incidence, aggressive
phenotype and poor outcome of breast cancer (BC) patients. For instance, hyperinsulinemia …

Advances on the anti-tumor mechanisms of the carotenoid Crocin

X Bao, J Hu, Y Zhao, R Jia, H Zhang, L Xia - PeerJ, 2023 - peerj.com
Saffron is located in the upper part of the crocus stigma of iridaceae, which has a long
history of medicinal use. Crocin (molecular formula C 44 H 64 O 24) is a natural floral …

[HTML][HTML] Metformin and HER2-positive breast cancer: Mechanisms and therapeutic implications

SS Bashraheel, H Kheraldine, S Khalaf… - Biomedicine & …, 2023 - Elsevier
Due to the strong association between diabetes and cancer incidents, several anti-diabetic
drugs, including metformin, have been examined for their anticancer activity. Metformin is a …