The landscape of aging

Y Cai, W Song, J Li, Y Jing, C Liang, L Zhang… - Science China Life …, 2022 - Springer
Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

Making sense of the ageing methylome

K Seale, S Horvath, A Teschendorff, N Eynon… - Nature Reviews …, 2022 - nature.com
Over time, the human DNA methylation landscape accrues substantial damage, which has
been associated with a broad range of age-related diseases, including cardiovascular …

A mammalian methylation array for profiling methylation levels at conserved sequences

A Arneson, A Haghani, MJ Thompson… - Nature …, 2022 - nature.com
Infinium methylation arrays are not available for the vast majority of non-human mammals.
Moreover, even if species-specific arrays were available, probe differences between them …

Universal DNA methylation age across mammalian tissues

AT Lu, Z Fei, A Haghani, TR Robeck, JA Zoller, CZ Li… - Nature aging, 2023 - nature.com
Aging, often considered a result of random cellular damage, can be accurately estimated
using DNA methylation profiles, the foundation of pan-tissue epigenetic clocks. Here, we …

Universal DNA methylation age across mammalian tissues

AT Lu, Z Fei, A Haghani, TR Robeck, JA Zoller, CZ Li… - BioRxiv, 2021 - biorxiv.org
Aging is often perceived as a degenerative process resulting from random accrual of cellular
damage over time. Despite this, age can be accurately estimated by epigenetic clocks based …

Biological clocks as age estimation markers in animals: a systematic review and meta‐analysis

LS Le Clercq, A Kotzé, JP Grobler… - Biological …, 2023 - Wiley Online Library
Various biological attributes associated with individual fitness in animals change predictably
over the lifespan of an organism. Therefore, the study of animal ecology and the work of …

The methylation landscape of giga-genome and the epigenetic timer of age in Chinese pine

J Li, F Han, T Yuan, W Li, Y Li, HX Wu, H Wei… - Nature …, 2023 - nature.com
Epigenetics has been revealed to play a crucial role in the long-term memory in plants.
However, little is known about whether the epigenetic modifications occur with age …

Epigenetic models developed for plains zebras predict age in domestic horses and endangered equids

B Larison, GM Pinho, A Haghani, JA Zoller… - Communications …, 2021 - nature.com
Effective conservation and management of threatened wildlife populations require an
accurate assessment of age structure to estimate demographic trends and population …

DNA methylation‐based biomarkers for ageing long‐lived cetaceans

KM Parsons, A Haghani, JA Zoller… - Molecular ecology …, 2023 - Wiley Online Library
Epigenetic approaches for estimating the age of living organisms are revolutionizing studies
of long‐lived species. Molecular biomarkers that allow age estimates from small tissue …

Multi-tissue DNA methylation aging clocks for sea lions, walruses and seals

TR Robeck, A Haghani, Z Fei, DM Lindemann… - Communications …, 2023 - nature.com
Age determination of wild animals, including pinnipeds, is critical for accurate population
assessment and management. For most pinnipeds, current age estimation methodologies …