The cause of fibrotic diseases, pathologies characterized by excessive production,
deposition, and contraction of extracellular matrix, is unknown. To understand the molecular …

The transforming growth factor ß (TGF-ß) family of hormonally active polypeptides have
attracted much attention because of their ability to control cellular functions that underwrite …

The generation of mice lacking specific components of the transforming growth factor‐β
(TGF‐β) signal tranduction pathway shows that TGF‐β is a key player in the development …

Transforming growth factor β (TGF-β) initiates its diverse cellular responses by binding to
and activating specific cell surface receptors that have intrinsic serine/threonine kinase …

Introduction. Accumulating evidence suggests that an imbalance between pro-angiogenic
(ie, vascular endothelial growth factor (VEGF) and placental growth factor (PlGF)) and anti …

Transforming growth factor-β (TGF-β) family members, which include TGF-βs, activins and
bone morphogenetic proteins, are pleiotropic cytokines that elicit cell type-specific effects in …

Endoglin is a transmembrane accessory receptor for transforming growth factor‐β (TGF‐β)
that is predominantly expressed on proliferating endothelial cells in culture and on …

Endoglin (CD105) is an accessory receptor for transforming growth factor beta (TGF-β) and
its expression is up-regulated in actively proliferating endothelial cells. Endoglin has been …

Angiogenesis is the propelling force for tumor growth and metastasis, and antiangiogenic
therapy represents one of the most promising modalities for cancer treatment. CD105 …

The transforming growth factor-β (TGF-β) superfamily of receptors comprises two groups of
transmembrane serine-threonine kinase receptors, so called type I, and type II receptors …