Statin therapy may lower plasma coenzyme Q10 (CoQ10) concentrations, but the evidence
as to the significance of this effect is unclear. We assessed the impact of statin therapy on …

While the proportion of patients with significant statin-associated adverse effects or
intolerance is very low, the increasing use and broadening indications have led to a …

O objetivo desta Diretriz é servir de apoio e auxiliar os médicos nas decisões referentes aos
seus pacientes, elaborando orientações que podem ser úteis na prática médica. A adoção …

ContextWhether statin therapy has beneficial effects on clinical outcomes in patients with
heart failure is unclear. ObjectiveTo evaluate the association between initiation of statin …

Objectives: The aim of this study was to investigate the relationship between plasma
coenzyme Q10 (CoQ10) and survival in patients with chronic heart failure (CHF) …

What is known and objective CoenzymeQ10 (CoQ10), or ubiquinone, is an endogenous
enzyme cofactor produced by most human cells. It is a potent antioxidant and is necessary …

Heart failure (HF) is a common, disabling, and costly disease. Despite major advances in
medical therapy, morbidity and mortality remain high, in part because current …

Over the past 2 decades our understanding of the pathologic mechanisms that lead to heart
failure (HF) has evolved from simplistic hemodynamic models to more complex models that …

Background—Small studies suggest that statins may improve mortality in patients with heart
failure (HF). Whether these results are generalizable to a broader group of patients with HF …

Abstract Coenzyme Q 10 (CoQ 10) is an essential cofactor in the mitochondrial electron
transport pathway, and is also a lipid-soluble antioxidant. It is endogenously synthesised via …