[HTML][HTML] Recognition of the SARS-CoV-2 receptor binding domain by neutralizing antibodies
Immediately from the outset of the COVID-19 pandemic, researchers from diverse
biomedical and biological disciplines have united to study the novel pandemic virus, SARS …
biomedical and biological disciplines have united to study the novel pandemic virus, SARS …
[HTML][HTML] Mutations of SARS-CoV-2 spike protein: Implications on immune evasion and vaccine-induced immunity
Responsible for more than 4.9 million deaths so far, COVID-19, caused by SARS-CoV-2, is
instigating devastating effects on the global health care system whose impacts could be …
instigating devastating effects on the global health care system whose impacts could be …
[HTML][HTML] Cryo-EM structures of SARS-CoV-2 spike without and with ACE2 reveal a pH-dependent switch to mediate endosomal positioning of receptor-binding …
The SARS-CoV-2 spike employs mobile receptor-binding domains (RBDs) to engage the
human ACE2 receptor and to facilitate virus entry, which can occur through low-pH …
human ACE2 receptor and to facilitate virus entry, which can occur through low-pH …
[HTML][HTML] Cross-neutralization of a SARS-CoV-2 antibody to a functionally conserved site is mediated by avidity
Most antibodies isolated from individuals with coronavirus disease 2019 (COVID-19) are
specific to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However …
specific to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However …
Potent pan huACE2-dependent sarbecovirus neutralizing monoclonal antibodies isolated from a BNT162b2-vaccinated SARS survivor
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants
of concern such as Omicron hampered efforts in controlling the ongoing coronavirus disease …
of concern such as Omicron hampered efforts in controlling the ongoing coronavirus disease …
[HTML][HTML] Deep geometric representations for modeling effects of mutations on protein-protein binding affinity
Modeling the impact of amino acid mutations on protein-protein interaction plays a crucial
role in protein engineering and drug design. In this study, we develop GeoPPI, a novel …
role in protein engineering and drug design. In this study, we develop GeoPPI, a novel …
[HTML][HTML] A large-scale systematic survey reveals recurring molecular features of public antibody responses to SARS-CoV-2
Global research to combat the COVID-19 pandemic has led to the isolation and
characterization of thousands of human antibodies to the SARS-CoV-2 spike protein …
characterization of thousands of human antibodies to the SARS-CoV-2 spike protein …
On-site detection of SARS-CoV-2 antigen by deep learning-based surface-enhanced Raman spectroscopy and its biochemical foundations
J Huang, J Wen, M Zhou, S Ni, W Le, G Chen… - Analytical …, 2021 - ACS Publications
A rapid, on-site, and accurate SARS-CoV-2 detection method is crucial for the prevention
and control of the COVID-19 epidemic. However, such an ideal screening technology has …
and control of the COVID-19 epidemic. However, such an ideal screening technology has …
[HTML][HTML] The effect of spike mutations on SARS-CoV-2 neutralization
C Rees-Spear, L Muir, SA Griffith, J Heaney, Y Aldon… - Cell reports, 2021 - cell.com
Multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines show
protective efficacy, which is most likely mediated by neutralizing antibodies recognizing the …
protective efficacy, which is most likely mediated by neutralizing antibodies recognizing the …
In vitro data suggest that Indian delta variant B. 1.617 of SARS‐CoV‐2 escapes neutralization by both receptor affinity and immune evasion
G Augusto, MO Mohsen, S Zinkhan, X Liu, M Vogel… - Allergy, 2022 - Wiley Online Library
Background Emerged mutations can be attributed to increased transmissibility of the B.
1.617 and B. 1.36 Indian delta variants of SARS‐CoV‐2, most notably substitutions …
1.617 and B. 1.36 Indian delta variants of SARS‐CoV‐2, most notably substitutions …