Biogenetic and biomimetic synthesis of natural bisditerpenoids: hypothesis and practices

Y Chang, C Sun, C Wang, X Huo, W Zhao… - Natural Product …, 2022 - pubs.rsc.org
Covering: up to March 2022 Bisditerpenoids, or diterpenoid dimers, are a group of natural
products with high structural variance, deriving from homo-or hetero-dimeric coupling of two …

Diterpenoids of terrestrial origin

JR Hanson - Natural Product Reports, 2013 - pubs.rsc.org
Covering January to December 2012. Previous review, Nat. Prod. Rep., 2012, 29, 890–898.
This review covers the isolation and chemistry of diterpenoids from terrestrial as opposed to …

Icetexane diterpenoids as Cav3. 2 T-type calcium channel inhibitors from Salvia prattii and analgesic effect of their Semi-synthesized derivatives

F Xia, SZ Du, MK Wu, R Liu, YS Ye, J Yang, G Xu… - Bioorganic …, 2022 - Elsevier
Ten new icetexane diterpenoids, salpratins E–N (1–10) and a known analogue (11) were
characterized from Salvia prattii Hemsl. Structurally, 1 is the first 19 (4→ 3)-abeo-icetexane …

Two Pairs of Enantiomeric Alkaloid Dimers from Macleaya cordata

CM Sai, DH Li, CM Xue, KB Wang, P Hu, YH Pei… - Organic …, 2015 - ACS Publications
Two pairs of enantiomeric alkaloid dimers,(±)-macleayins A (1) and B (2), representing a
novel dimerization pattern of two different types of alkaloids via a C–C σ-bond, were isolated …

Tandem C–H oxidation/cyclization/rearrangement and its application to asymmetric syntheses of (−)-brussonol and (−)-przewalskine E

ZW Jiao, YQ Tu, Q Zhang, WX Liu, SY Zhang… - Nature …, 2015 - nature.com
Natural products are a vital source of lead compounds in drug discovery. Development of
efficient tandem reactions to build useful compounds and apply them to the synthesis of …

Efficient synthesis of icetexane diterpenes and apoptosis inducing effect by upregulating BiP-ATF4-CHOP axis in colorectal cells

W Cao, T Liu, S Yang, M Liu, Z Pan… - Journal of Natural …, 2021 - ACS Publications
We herein present an efficient and robust synthetic strategy toward 12 icetexane diterpenes
and their derivatives, which features a PPh3/DIAD-mediated rearrangement of the reduced …

Sterhirsutins A and B, Two New Heterodimeric Sesquiterpenes with a New Skeleton from the Culture of Stereum hirsutum Collected in Tibet Plateau

QY Qi, L Bao, JW Ren, JJ Han, ZY Zhang, Y Li… - Organic …, 2014 - ACS Publications
Two new heterodimeric sesquiterpenes, sterhirsutins A (1) and B (2), and two new
sesquiterpenes, hirsutic acids D–E (3 and 4), were identified from the culture of Stereum …

Abietane derived diterpenoids as Cav3. 1 antagonists from Salvia digitaloides

J Zhao, S Du, K Hu, Y Hu, F Xia, Y Ye, J Yang… - Chinese Chemical …, 2023 - Elsevier
Nineteen diterpenoids, including saldigitin A (1) bearing an unprecedented 10-methylated
6/7/6 carbon ring system, two new icetexanes (2, 3), and two new nor-abietanes (5, 6) were …

Recent developments with icetexane natural products

AA Naeini, AA Ziegelmeier… - Chemistry & …, 2022 - Wiley Online Library
Icetexane diterpenoids are a diverse family of natural products sourced from several species
of terrestrial plants. Icetexanes exhibit a broad array of biological activities and together with …

Teotihuacanin, a Diterpene with an Unusual Spiro-10/6 System from Salvia amarissima with Potent Modulatory Activity of Multidrug Resistance in Cancer Cells

E Bautista, M Fragoso-Serrano, RA Toscano… - Organic …, 2015 - ACS Publications
Teotihuacanin (1), an unusual rearranged clerodane diterpene with a new carbon skeleton
containing a spiro-10/6 bicyclic system, was isolated from the leaves and flowers of Salvia …