Huntington disease (HD) is an autosomal dominant neurodegenerative disorder with midlife
onset characterized by psychiatric, cognitive, and motor symptoms. Death occurs between …

It has been five years since the elucidation of the genetic mutation underlying the
pathogenesis of Huntington's disease (HD)(97), however the precise mechanism of the …

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder
characterized by motor, cognitive and psychiatric manifestations. Since the mutation …

Huntington's disease (HD) pathology is well understood at a histological level but a
comprehensive molecular analysis of the effect of the disease in the human brain has not …

Expanded polyglutamine repeats have been proposed to cause neuronal degeneration in
Huntington's disease (HD) and related disorders, through abnormal interactions with other …

Huntington's disease (HD) is an autosomal dominant progressive neurodegenerative
disorder that prominently affects the basal ganglia, leading to affective, cognitive, behavioral …

Huntington's disease (HD) results from polyglutamine expansion in huntingtin (htt), a protein
with several consensus caspase cleavage sites. Despite the identification of htt fragments in …

While a basal ganglia with striatal and pallidal subdivisions is1 clearly present in many
extant anamniote species, this basal ganglia is cell sparse and receives only a relatively …

Huntingtin is a cytoplasmic protein that is found in neurons and somatic cells. In patients with
Huntington's disease (HD), the NH2-terminal region of huntingtin has an expanded …

The immunohistochemical localization of huntingtin was examined in the Huntington's
disease (HD) brain with an antibody that recognizes the wild‐type and mutant proteins …