[HTML][HTML] Selective estrogen receptor modulators (SERMs) and selective estrogen receptor degraders (SERDs) in cancer treatment

HK Patel, T Bihani - Pharmacology & therapeutics, 2018 - Elsevier
Breast cancer is the most frequently diagnosed cancer in women, with estrogen receptor
positive (ER+) breast cancer making up approximately 75% of all breast cancers diagnosed …

Designer self‐assembling peptide hydrogels to engineer 3D cell microenvironments for cell constructs formation and precise oncology remodeling in ovarian cancer

Z Yang, H Xu, X Zhao - Advanced Science, 2020 - Wiley Online Library
Designer self‐assembling peptides form the entangled nanofiber networks in hydrogels by
ionic‐complementary self‐assembly. This type of hydrogel has realistic biological and …

The highly effective therapy of ovarian cancer by Bismuth-doped oxygen-deficient BaTiO3 with enhanced sono-piezocatalytic effects

S Cheng, Y Luo, J Zhang, R Shi, S Wei, K Dong… - Chemical Engineering …, 2022 - Elsevier
Ovarian cancer (OC) is the leading cause of death of gynecological malignancy.
Sonodynamic therapy (SDT) with high penetration ability and minimal invasion is …

Estrogen signaling and its potential as a target for therapy in ovarian cancer

SP Langdon, CS Herrington, RL Hollis, C Gourley - Cancers, 2020 - mdpi.com
The estrogen receptor (ER) has functionality in selected ovarian cancer subtypes and
represents a potential target for therapy. The majority (> 80%) of high grade serous, low …

Current understanding on why ovarian cancer is resistant to immune checkpoint inhibitors

A Pawłowska, A Rekowska, W Kuryło… - International journal of …, 2023 - mdpi.com
The standard treatment of ovarian cancer (OC) patients, including debulking surgery and
first-line chemotherapy, is unsatisfactory because of recurrent episodes in the majority …

Hormone therapy for ovarian cancer: Emphasis on mechanisms and applications

H Li, Y Liu, Y Wang, X Zhao, X Qi - Oncology reports, 2021 - spandidos-publications.com
Ovarian cancer (OC) remains the leading cause of mortality due to gynecological
malignancies. Epidemiological studies have demonstrated that steroid hormones released …

Cancer-associated thrombosis: risk factors, molecular mechanisms, future management

MS Hamza, SA Mousa - Clinical and Applied Thrombosis …, 2020 - journals.sagepub.com
Venous thromboembolism (VTE) is a major health problem in patients with cancer. Cancer
augments thrombosis and causes cancer-associated thrombosis (CAT) and vice versa …

Identification of an autophagy-related signature for prognosis and immunotherapy response prediction in ovarian cancer

J Ding, C Wang, Y Sun, J Guo, S Liu, Z Cheng - Biomolecules, 2023 - mdpi.com
Background: Ovarian cancer (OC) is one of the most malignant tumors in the female
reproductive system, with a poor prognosis. Various responses to treatments including …

[HTML][HTML] Phase II trial of ribociclib and letrozole in patients with relapsed oestrogen receptor-positive ovarian or endometrial cancers

G Colon-Otero, V Zanfagnin, X Hou, NR Foster… - ESMO open, 2020 - Elsevier
Objective We describe a phase II clinical trial of the combination of ribociclib and letrozole
for treatment of relapsed oestrogen receptor (ER)-positive ovarian cancer (OC) and …

Loss of E-cadherin Enhances IGF1–IGF1R pathway activation and sensitizes breast cancers to anti-IGF1R/InsR inhibitors

AM Nagle, KM Levine, N Tasdemir, JA Scott… - Clinical Cancer …, 2018 - AACR
Purpose: Insulin-like growth factor 1 (IGF1) signaling regulates breast cancer initiation and
progression and associated cancer phenotypes. We previously identified E-cadherin …