During angiogenesis, new vessels emerge from existing endothelial lined vessels to
promote the degradation of the vascular basement membrane and remodel the extracellular …

Metastasis is an inefficient process in which the vast majority of cancer cells are fated to die,
partly because they experience oxidative stress. Metastasizing cancer cells migrate through …

During metastasis, malignant cells escape the primary tumor, intravasate lymphatic vessels,
and reach draining sentinel lymph nodes before they colonize distant organs via the blood …

The growth of lymphatic vessels (lymphangiogenesis) is actively involved in a number of
pathological processes including tissue inflammation and tumor dissemination but is …

Solid tumors require blood vessels for growth and dissemination, and lymphatic vessels as
additional conduits for metastatic spread. The identification of growth factor receptor …

Vascular endothelial growth factors and their endothelial tyrosine kinase receptors are
central regulators of vasculogenesis, angiogenesis and lymphangiogenesis. VEGF …

Metastatic spread of cancer through the lymphatic system affects hundreds of thousands of
patients yearly. Growth of new lymphatic vessels, lymphangiogenesis, is activated in cancer …

Tumor metastases are responsible for approximately 90% of all cancer-related deaths.
Although many patients can be cured, in the US and UK, cancer still causes 730,000 deaths …

The prognosis for bladder cancer patients with lymph node (LN) metastasis is dismal and
only minimally improved by current treatment modalities. Elucidation of the molecular …

Tumor-infiltrating myeloid cells (TIMs) support tumor growth by promoting angiogenesis and
suppressing antitumor immune responses. CSF-1 receptor (CSF1R) signaling is important …