[HTML][HTML] Conceptualizing mental disorders as deviations from normative functioning

AF Marquand, SM Kia, M Zabihi, T Wolfers… - Molecular …, 2019 - nature.com
Normative models are a class of emerging statistical techniques useful for understanding the
heterogeneous biology underlying psychiatric disorders at the level of the individual …

The normative modeling framework for computational psychiatry

S Rutherford, SM Kia, T Wolfers, C Fraza, M Zabihi… - Nature protocols, 2022 - nature.com
Normative modeling is an emerging and innovative framework for mapping individual
differences at the level of a single subject or observation in relation to a reference model. It …

Evidence for embracing normative modeling

S Rutherford, P Barkema, IF Tso, C Sripada… - Elife, 2023 - elifesciences.org
In this work, we expand the normative model repository introduced in Rutherford et al.,
2022a to include normative models charting lifespan trajectories of structural surface area …

Charting brain growth and aging at high spatial precision

S Rutherford, C Fraza, R Dinga, SM Kia, T Wolfers… - elife, 2022 - elifesciences.org
Defining reference models for population variation, and the ability to study individual
deviations is essential for understanding inter-individual variability and its relation to the …

Resolving heterogeneity in schizophrenia through a novel systems approach to brain structure: individualized structural covariance network analysis

Z Liu, L Palaniyappan, X Wu, K Zhang, J Du… - Molecular …, 2021 - nature.com
Reliable mapping of system-level individual differences is a critical first step toward
precision medicine for complex disorders such as schizophrenia. Disrupted structural …

Genesis, modelling and methodological remedies to autism heterogeneity

J Rabot, EM Rødgaard, R Joober, G Dumas… - Neuroscience & …, 2023 - Elsevier
Diagnostic criteria used in autism research have undergone a shift towards the inclusion of a
larger population, paralleled by increasing, but variable, estimates of autism prevalence …

Toward neurosubtypes in autism

SJ Hong, JT Vogelstein, A Gozzi, BC Bernhardt… - Biological …, 2020 - Elsevier
There is a consensus that substantial heterogeneity underlies the neurobiology of autism
spectrum disorder (ASD). As such, it has become increasingly clear that a dissection of …

From pattern classification to stratification: towards conceptualizing the heterogeneity of Autism Spectrum Disorder

T Wolfers, DL Floris, R Dinga, D van Rooij… - Neuroscience & …, 2019 - Elsevier
Pattern classification and stratification approaches have increasingly been used in research
on Autism Spectrum Disorder (ASD) over the last ten years with the goal of translation …

Towards precise resting-state fMRI biomarkers in psychiatry: synthesizing developments in transdiagnostic research, dimensional models of psychopathology, and …

L Parkes, TD Satterthwaite, DS Bassett - Current Opinion in Neurobiology, 2020 - Elsevier
Highlights•Resting-state fMRI biomarkers in psychiatry often lack disorder specificity.•
Transdiagnostic study designs allow direct assessment of biomarker specificity.•p-factor …

[HTML][HTML] Transdiagnostic dimensions of psychopathology explain individuals' unique deviations from normative neurodevelopment in brain structure

L Parkes, TM Moore, ME Calkins, PA Cook… - Translational …, 2021 - nature.com
Psychopathology is rooted in neurodevelopment. However, clinical and biological
heterogeneity, together with a focus on case-control approaches, have made it difficult to link …