Rapidly activating and inactivating cardiac transient outward K+ currents, Ito, are expressed
in most mammalian cardiomyocytes, and contribute importantly to the early phase of action …

In this review, subtypes of functional α1-adrenoceptor are discussed. These are cell
membrane receptors, belonging to the seven-transmembrane-spanning G-protein-linked …

Compartmentation of signalling allows multiple stimuli to achieve diverse cellular responses
with only a limited pool of second messengers. This spatial control of signalling is achieved …

Background/Aims: Acute myocardial infarction (AMI) is a devastating cardiovascular disease
with a high rate of morbidity and mortality, partly due to enhanced arrhythmogenicity …

Membrane-associated guanylate kinase (MAGUK) proteins are major determinants of the
organization of ion channels in the plasma membrane in various cell types. Here, we …

Background and purpose: Testosterone alleviates symptoms in patients with ischaemic
heart disease. Androgen receptors are present in the heart, and testosterone upregulates …

The multifunctional Ca2+/calmodulin-dependent protein kinase II (CaMKII) is activated by
elevated intracellular Ca2+ (Ca2+ i), and mice with chronic myocardial CaMKII inhibition …

SIRT6 is a member of the sirtuin family of class III histone deacetylases. It plays important
roles in regulating genomic stability, metabolism, stress response and aging. Our previous …

The current manuscript reviews the evidence whether and how subtypes of α1-adrenergic
receptors, ie α1A-, α1B-and α1D-adrenergic receptors, differentially couple to signal …

In this work we have combined biochemical and electrophysiological approaches to explore
the modulation of rat ventricular transient outward K+ current (I to) by calmodulin kinase II …