Diabetic nephropathy (DN) is the leading cause of end‐stage renal disease worldwide.
Chronic hyperglycemia and high blood pressure are the main risk factors for the …

Coronavirus infections of multiple origins have spread to date worldwide, causing severe
respiratory diseases. Seven coronaviruses that infect humans have been identified: HCoV …

Ferroptosis is a form of regulated cell death that may facilitate the selective elimination of
tumor cells. The tumor suppressor p53 (TP53) has been demonstrated to promote …

Abstract Dipeptidyl peptidase-4 (DPP4) is a widely expressed enzyme transducing actions
through an anchored transmembrane molecule and a soluble circulating protein. Both …

The combination of obesity and hypertension is associated with high morbidity and mortality
because it leads to cardiovascular and kidney disease. Potential mechanisms linking …

Adipose tissue depots in distinct anatomical locations mediate key aspects of metabolism,
including energy storage, nutrient release, and thermogenesis. Although adipocytes make …

Type-II diabetes mellitus (T2DM) results from a combination of genetic and lifestyle factors,
and the prevalence of T2DM is increasing worldwide. Clinically, both α-glucosidase and α …

Perivascular adipose tissue (PVAT), the adipose tissue that surrounds most of the
vasculature, has emerged as an active component of the blood vessel wall regulating …

Endothelial-to-mesenchymal transition (EndMT) is a process that encompasses extensive
transcriptional reprogramming of activated endothelial cells leading to a shift toward …

The discovery of incretin-based medications represents a major therapeutic advance in the
pharmacological management of type 2 diabetes mellitus (T2DM), as these agents avoid …