Influenza, a severe viral infection of the respiratory system, is responsible for a significant
morbidity and mortality due to both annual epidemics and unpredictable pandemics. In the …

Seasonal and pandemic influenza have caused high morbidity and mortality worldwide.
Recent emergence of influenza A H5N1 and H1N1 strains has heightened concern …

As part of the Community Structure-Activity Resource (CSAR) center, a set of 343 high-
quality, protein–ligand crystal structures were assembled with experimentally determined K …

Neuraminidase (NA) is a membrane surface antigen which helps in the release of influenza
viruses from the host cells after replication. Anti-influenza drugs such as zanamivir bind with …

To discover group-1-specific neuraminidase (NA) inhibitors that are especially involved in
combating the H5N1 virus, two series of oseltamivir derivatives were designed and …

Some water molecules in binding sites are important for intermolecular interactions and
stability. The way binding site explicit water molecules are dealt with affects the diversity and …

Carnosine is an endogenous dipeptide abundant in the central nervous system, where by
acting as intracellular pH buffering molecule, Zn/Cu ion chelator, antioxidant and anti …

A series of thiazolidine-4-carboxylic acid derivatives were synthesized and evaluated for
their ability to inhibit neuraminidase (NA) of influenza A virus. All the compounds were …

Due to the emergence of highly pathogenic and oseltamivir-resistant influenza viruses, there
is an urgent need to develop new anti-influenza agents. Herein, five subseries of oseltamivir …

Since March 2009, the rapid spread of infection during the recent A/H1N1 swine flu
pandemic has raised concerns of a far more dangerous outcome should this virus become …