Recent advancements in typical friedel–crafts alkylation reactions focused on targeting arene nucleophiles

S Singh, CK Hazra - Synthesis, 2024 - thieme-connect.com
This review delves into recent advances and significant breakthroughs in the field of the
catalytic Friedel–Crafts alkylation of targeted arenes or heteroarenes. Though a few earlier …

A recent update on the environment friendly methodologies to synthesize bis (indolyl) methane and 3, 3-di (3-indolyl)-2-indolone derivatives

P Kamboj, V Tyagi - Tetrahedron, 2023 - Elsevier
Indole, widely recognized as a versatile category of heterocyclic frameworks that contain
nitrogen is extensively employed in the synthesis of various organic compounds due to their …

Palladium/Lewis Acid Co-catalyzed Cyclocarbonylation of (2-Aminoaryl)(aryl) methanols: An Access to 3-Aryl-indolin-2-ones

T Xie, G Hu, S Zhang, T Xu, F Zeng - The Journal of Organic …, 2023 - ACS Publications
A benign approach to valuable 3-aryl-indolin-2-ones was developed based on palladium
(II)/Lewis acid-cocatalyzed cyclocarbonylation of readily available (2-aminoaryl)(aryl) …

Modular synthesis of 3, 3-disubstituted oxindoles from nitrones and acrylic acids

H Suzuki, K Sekino, S Kondo, R Minamikawa… - Organic & …, 2024 - pubs.rsc.org
We developed a modular synthesis for 3, 3-disubstituted oxindoles, utilising readily
accessible nitrones and acrylic acids. This approach facilitates the preparation of a diverse …

Synthesis of unsymmetrical diaryl oxindoles/isoquinolinediones using 2-phenoxy-1 H-benzo [d] imidazole as an integrated diarylating reagent

G Xu, Y Wang, K Liu, Y Jiang, X Zhang… - Organic Chemistry …, 2023 - pubs.rsc.org
Presented herein is a novel synthesis of unsymmetrical 3, 3-diaryl oxindoles and 4, 4-diaryl
isoquinolinediones through the cascade reactions of 2-phenoxy-1H-benzo [d] imidazoles …

Direct Synthesis of α-Ketoamides via Copper-Catalyzed Reductive Amidation of Nitroarenes with α-Oxocarboxylic Acids

J Liu, J Yao, J Du, L Yu, W Duan… - The Journal of Organic …, 2024 - ACS Publications
Nitroarenes are known for their stability, low toxicity, easy availability, and cost-effectiveness,
making them one of the most fundamental chemical feedstocks. The direct utilization of …

Copper-Catalyzed Chemoselective O-Arylation of Oxindoles: Access to Cyclic Aryl Carboxyimidates

PR Singh, M Lamba, A Goswami - The Journal of Organic …, 2024 - ACS Publications
We have developed a highly efficient base-and additive-free chemoselective CuO-catalyzed
strategy for the O-arylation of 2-oxindoles to synthesize 2-phenoxy-3 H-indole and 2 …

One-Pot Sequential Synthesis of 3, 3′-or 2, 3′-Bis (indolyl) methanes by Using 1, 3-Dithiane as the Methylene Source

K Dong, J Li, RP Li, M Mao, J Liu… - The Journal of Organic …, 2022 - ACS Publications
A simple and efficient method for structurally diverse symmetrical and unsymmetrical 3, 3′-
and 2, 3′-bisindolylmethanes has been developed through a one-pot sequential reaction …

Nondirected Ortho C–H Arylation for One-Pot Synthesis of Biaryl Scaffolds via In Situ Generated Mixed Acetal

A Tyagi, H Gautam, K Tripathi… - The Journal of Organic …, 2024 - ACS Publications
Herein, we introduce a mild and efficient method for synthesizing aniline biaryls and
unsymmetrical phenol biaryls through iodine-catalyzed coupling of quinone imine ketals …

Metal-Free Switchable Chemo-and Regioselective Alkylation of Oxindoles Using Secondary Alcohols

M Lamba, PR Singh, Tanmay… - The Journal of Organic …, 2024 - ACS Publications
In this study, we have disclosed N-alkylation and C-alkylation reactions of 2-oxindoles with
secondary alcohols. Interestingly, these chemoselective reactions are tunable by changing …