HLA-G: an immune checkpoint molecule

ED Carosella, N Rouas-Freiss, D Tronik-Le Roux… - Advances in …, 2015 - Elsevier
HLA-G is a molecule that was first known to confer protection to the fetus from destruction by
the immune system of its mother, thus critically contributing to fetal–maternal tolerance. The …

Human leukocyte antigen (HLA) and immune regulation: how do classical and non-classical HLA alleles modulate immune response to human immunodeficiency …

NB Crux, S Elahi - Frontiers in immunology, 2017 - frontiersin.org
The genetic factors associated with susceptibility or resistance to viral infections are likely to
involve a sophisticated array of immune response. These genetic elements may modulate …

Control and prevention of infectious diseases from a One Health perspective

JH Ellwanger, ABG Veiga, VL Kaminski… - … and Molecular Biology, 2021 - SciELO Brasil
The ongoing COVID-19 pandemic has caught the attention of the global community and
rekindled the debate about our ability to prevent and manage outbreaks, epidemics, and …

Insights into HLA-G Genetics Provided by Worldwide Haplotype Diversity

EC Castelli, J Ramalho, IOP Porto, THA Lima… - Frontiers in …, 2014 - frontiersin.org
Human leukocyte antigen G (HLA-G) belongs to the family of non-classical HLA class I
genes, located within the major histocompatibility complex (MHC). HLA-G has been the …

HLA‐G: Function, polymorphisms and pathology

A Arnaiz‐Villena, I Juarez… - International Journal …, 2021 - Wiley Online Library
HLA‐G immune modulatory genes and molecules are presently being studied by a
widespread number of research groups. In the present study, we do not aim to be exhaustive …

HLA-G molecules in autoimmune diseases and infections

R Rizzo, D Bortolotti, S Bolzani, E Fainardi - Frontiers in immunology, 2014 - frontiersin.org
Human leukocyte antigen (HLA)-G molecule, a non-classical HLA-Ib molecule, is less
polymorphic when compared to classical HLA class I molecules. Human leukocyte antigen …

The dual role of HLA‐G in cancer

N Rouas-Freiss, P Moreau, J LeMaoult… - Journal of …, 2014 - Wiley Online Library
We here review the current data on the role of HLA‐G in cancer based on recent findings of
an unexpected antitumor activity of HLA‐G in hematological malignancies. For the past …

Immunomodulatory properties of HLA‐G in infectious diseases

L Amiot, N Vu, M Samson - Journal of immunology research, 2014 - Wiley Online Library
HLA‐G is a nonclassical major histocompatibility complex molecule first described at the
maternal‐fetal interface, on extravillous cytotrophoblasts. Its expression is restricted to some …

The Role of HLA-G Molecule and HLA-G Gene Polymorphisms in Tumors, Viral Hepatitis, and Parasitic Diseases

FC Dias, EC Castelli, CVA Collares, P Moreau… - Frontiers in …, 2015 - frontiersin.org
Considering that the non-classical HLA-G molecule has well-recognized tolerogenic
properties, HLA-G expression is expected to be deleterious when present in tumor cells and …

Human leukocyte antigen (HLA)-G and cervical cancer immunoediting: a candidate molecule for therapeutic intervention and prognostic biomarker?

F Gimenes, JJV Teixeira, ALP de Abreu… - … et Biophysica Acta (BBA …, 2014 - Elsevier
While persistent infection with oncogenic types of human Papillomavirus (HPV) is required
for cervical epithelial cell transformation and cervical carcinogenesis, HPV infection alone is …