Genomic instability is a primary cause and fundamental feature of human cancer. However,
all cancer cell genotypes generally translate into several common pathophysiological …

Metastasis causes most cancer-related deaths; however, the efficacy of anti-metastatic drugs
is limited by incomplete understanding of the biological mechanisms that drive metastasis …

Smart drug delivery systems (DDSs) have attracted the attention of many scientists, as
carriers that can be stimulated by changes in environmental parameters such as …

Simple Summary The formation of new blood vessels from already existing ones is a
process of high clinical relevance, since it is of great importance for both physiological and …

Many genes and molecules that drive tissue patterning during organogenesis and tissue
regeneration have been discovered. Yet, we still lack a full understanding of how these …

Chemotherapy has been used for cancer treatment already for almost 70 years by targeting
the proliferation potential and metastasising ability of tumour cells. Despite the progress …

Hydrogels are increasingly employed as multidimensional cell culture platforms often with a
necessity that they respond to or control the cellular environment. Specifically, synthetic …

Tumor progression alters the composition and physical properties of the extracellular matrix.
Particularly, increased matrix stiffness has profound effects on tumor growth and metastasis …

The general progression of cancer drug development involves in vitro testing followed by
safety and efficacy evaluation in clinical trials. Due to the expense of bringing candidate …

The vascular endothelium is a dynamic cellular “organ” that controls passage of nutrients
into tissues, maintains the flow of blood, and regulates the trafficking of leukocytes. In …