The ability of cells to respond to mechanical forces is critical for numerous biological
processes. Emerging evidence indicates that external mechanical forces trigger changes in …

It is well established that cells sense chemical signals from their local microenvironment and
transduce them to the nucleus to regulate gene expression programmes. Although a number …

Mechanotransduction is the ability of a cell to sense mechanical cues from its
microenvironment and convert them into biochemical signals to elicit adaptive transcriptional …

Cells in tissues experience a plethora of forces that regulate their fate and modulate
development and homeostasis. Cells sense mechanical cues through localized …

Cellular behavior is continuously affected by microenvironmental forces through the process
of mechanotransduction, in which mechanical stimuli are rapidly converted to biochemical …

Cells and tissues can sense and react to the modifications of the physico-chemical
properties of the extracellular environment (ECM) through integrin-based adhesion sites and …

Stem cells interpret signals from their microenvironment while simultaneously modifying the
niche through secreting factors and exerting mechanical forces. Many soluble stem cell cues …

Over the past decade, researchers have highlighted the importance of mechanical cues of
the metastatic niche such as matrix stiffness, topography, mechanical stresses, and …

Fibroblasts exhibit heterogeneous cell geometries in tissues and integrate both mechanical
and biochemical signals in their local microenvironment to regulate genomic programs via …

Current models for the folding of the human genome see a hierarchy stretching down from
chromosome territories, through A/B compartments and topologically-associating domains …