Sex differences in the epilepsies and associated comorbidities: implications for use and development of pharmacotherapies
The epilepsies are common neurologic disorders characterized by spontaneous recurrent
seizures. Boys, girls, men, and women of all ages are affected by epilepsy and, in many …
seizures. Boys, girls, men, and women of all ages are affected by epilepsy and, in many …
Epileptic channelopathies caused by neuronal Kv7 (KCNQ) channel dysfunction
Seizures are the most common neurological manifestation in the newborn period, with an
estimated incidence of 1.8–3.5 per 1000 live births. Prolonged or intractable seizures have a …
estimated incidence of 1.8–3.5 per 1000 live births. Prolonged or intractable seizures have a …
Neural mechanisms underlying repetitive behaviors in rodent models of autism spectrum disorders
T Gandhi, CC Lee - Frontiers in cellular neuroscience, 2021 - frontiersin.org
Autism spectrum disorder (ASD) is comprised of several conditions characterized by
alterations in social interaction, communication, and repetitive behaviors. Genetic and …
alterations in social interaction, communication, and repetitive behaviors. Genetic and …
[HTML][HTML] Muscarinic M1 receptors modulate working memory performance and activity via KCNQ potassium channels in the primate prefrontal cortex
Working memory relies on the dorsolateral prefrontal cortex (dlPFC), where microcircuits of
pyramidal neurons enable persistent firing in the absence of sensory input, maintaining …
pyramidal neurons enable persistent firing in the absence of sensory input, maintaining …
Rare genetic brain disorders with overlapping neurological and psychiatric phenotypes
KJ Peall, MJ Owen, J Hall - Nature Reviews Neurology, 2024 - nature.com
Understanding rare genetic brain disorders with overlapping neurological and psychiatric
phenotypes is of increasing importance given the potential for developing disease models …
phenotypes is of increasing importance given the potential for developing disease models …
The role of Kv7. 2 in neurodevelopment: insights and gaps in our understanding
N Dirkx, F Miceli, M Taglialatela… - Frontiers in …, 2020 - frontiersin.org
Kv7. 2 subunits encoded by the KCNQ2 gene constitute a critical molecular component of
the M-current, a subthreshold voltage-gated potassium current controlling neuronal …
the M-current, a subthreshold voltage-gated potassium current controlling neuronal …
KCNQ2 and KCNQ5 form heteromeric channels independent of KCNQ3
H Soh, K Springer, K Doci… - Proceedings of the …, 2022 - National Acad Sciences
KCNQ2 and KCNQ3 channels are associated with multiple neurodevelopmental disorders
and are also therapeutic targets for neurological and neuropsychiatric diseases. For more …
and are also therapeutic targets for neurological and neuropsychiatric diseases. For more …
The Role of Kv7 Channels in Neural Plasticity and Behavior
Activity-dependent persistent changes in neuronal intrinsic excitability and synaptic strength
are widely thought to underlie learning and memory. Voltage-gated KCNQ/Kv7 potassium …
are widely thought to underlie learning and memory. Voltage-gated KCNQ/Kv7 potassium …
Kv7/KCNQ potassium channels in cortical hyperexcitability and juvenile seizure-related death in Ank2-mutant mice
Autism spectrum disorders (ASD) represent neurodevelopmental disorders characterized by
social deficits, repetitive behaviors, and various comorbidities, including epilepsy. ANK2 …
social deficits, repetitive behaviors, and various comorbidities, including epilepsy. ANK2 …
Spontaneous seizure and memory loss in mice expressing an epileptic encephalopathy variant in the calmodulin-binding domain of Kv7.2
Epileptic encephalopathy (EE) is characterized by seizures that respond poorly to
antiseizure drugs, psychomotor delay, and cognitive and behavioral impairments. One of the …
antiseizure drugs, psychomotor delay, and cognitive and behavioral impairments. One of the …