Over the past decade, scientific discovery games (SDGs) have emerged as a viable
approach for biomedical research, engaging hundreds of thousands of volunteer players …

Functional design of ribosomes with mutant ribosomal RNA (rRNA) can expand
opportunities for understanding molecular translation, building cells from the bottom-up, and …

An RNA design algorithm takes a target RNA structure and finds a sequence that folds into
that structure. This is fundamentally important for engineering therapeutics using RNA …

Solving the RNA inverse folding problem, also known as the RNA design problem, is critical
to advance several scientific fields like bioengineering, yet existing approaches have had …

Motivation RNA design is the search for a sequence or set of sequences that will fold to
desired structure, also known as the inverse problem of RNA folding. However, the …

RNAs self-interact through hydrogen-bond base-pairing between nucleotides and fold into
specific, stable structures that substantially govern their biochemical behaviour …

RNA design is the search for a sequence or set of sequences that will fold into predefined
structures, also known as the inverse problem of RNA folding. While numerous RNA design …

Abstract The RNA Inverse Folding problem comes from computational biology. The goal is to
find a molecule that has a given folding. It is important for scientific fields such as …

Emerging RNA-based approaches to disease detection and gene therapy require RNA
sequences that fold into specific base-pairing patterns, but computational algorithms …

The negative structural design of RNAs, also called Inverse folding, consists in building a
synthetic nucleotides sequence adopting a targeted secondary structure as its Minimum …